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Order Code MISMA - GOKEY MMAAF Methylmalonic Acid (MMA), Amniotic Fluid

Additional Codes

Mayo Test ID:  MMAAF

Reporting Name

Methylmalonic Acid, AF

Useful For

Specific prenatal diagnostic marker for methylmalonic acidemia

Specimen Type

Amniotic Fld

Advisory Information

Mayo genetic counselor or consultant approval is required prior to ordering test, call 800-533-1710.

Specimen Required

Container/Tube: Amniotic fluid container

Specimen Volume: 5-10 mL

Collection Instructions:

1. Obtain specimen during 16 to 19 weeks of gestation.

2. Draw 25 to 30 mL of amniotic fluid and spin down.

3. Send cell-free supernatant specimen.

Specimen Minimum Volume

2 mL

Specimen Stability Information

Specimen Type Temperature Time
Amniotic Fld Frozen (preferred) 45 days
  Refrigerated  45 days
  Ambient  72 hours

Reject Due To









Reference Values

<1.50 nmol/mL

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Day(s) and Time(s) Performed

Monday through Friday; Continuously

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
MMAAF Methylmalonic Acid, AF In Process


Result ID Test Result Name Result LOINC Value
81921 Methylmalonic Acid, AF 34627-0
21121 Interpretation 59462-2


New York Clients-Informed consent is required. Please document on the request form or electronic order that a copy is on file. An Informed Consent for Genetic Testing (T576) is available in Special Instructions.