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HelpOrder Code PNTO Streptococcus pneumoniae IgG Antibodies, Total, Serum
Ordering Guidance
This test is the preferred test for patients previously tested for Streptococcus pneumoniae antibodies (as part of follow up testing or part of pre/post vaccine assessment).
The preferred test for patients being evaluated for possible immunodeficiency or for assessment of pneumococcal vaccination response (initial evaluation) is PNTOR / Streptococcus pneumoniae IgG Antibodies, Total, with Reflex, Serum.
The preferred test for patients previously tested for S pneumoniae serotypes (as part of follow up testing or part of pre/post vaccine assessment) is PN23M / Streptococcus pneumoniae IgG Antibodies, 23 Serotypes, Serum.
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL Serum
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Useful For
Assessing the IgG antibody response to active immunization with nonconjugated 23-valent pneumococcal vaccines
Assessing the IgG antibody response to active immunization with conjugated 13-valent, 15-valent and 20-valent pneumococcal vaccines
Determining the ability of an individual to produce an antibody response to polysaccharide antigens as part of an evaluation for humoral or combined immunodeficiencies, primarily in patients previously tested for Streptococcus pneumoniae antibodies
Method Name
Enzyme-Linked Immunosorbent Assay (ELISA)
Reporting Name
S. pneumoniae IgG Ab, Total, SSpecimen Type
SerumSpecimen Minimum Volume
Serum: 0.3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 21 days |
| Frozen | 21 days |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
| Heat-inactivated specimen | Reject |
Reference Values
≥9.7 mcg/mL
Method Description
Testing for IgG antibodies to Streptococcus pneumoniae serotypes is performed using a laboratory-developed immunoassay.(Unpublished Mayo method)
Day(s) Performed
Tuesday, Thursday
Performing Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
86317
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| PNTO | S. pneumoniae IgG Ab, Total, S | 43236-9 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| PNTO | S. pneumoniae IgG Ab, Total, S | 43236-9 |