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Order Code CDTA Carbohydrate Deficient Transferrin, Adult, Serum

Reporting Name

Carb Def Transferrin, Adult, S

Useful For

Indicating chronic alcohol abuse

 

This test is not appropriate for screening patients for congenital disorders of glycosylation.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum


Ordering Guidance


This test is for evaluation of alcohol abuse. If the ordering physician is looking for congenital disorders of glycosylation, order CDG / Carbohydrate Deficient Transferrin for Congenital Disorders of Glycosylation, Serum.



Necessary Information


1. Patient's age is required.

2. Reason for testing is required if patient is younger than 21 years.



Specimen Required


Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.1 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Specimen Minimum Volume

0.05 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Frozen (preferred) 45 days
  Refrigerated  28 days
  Ambient  7 days

Reference Values

≤0.10

0.11-0.12 (indeterminate)

Day(s) Performed

Wednesday

CPT Code Information

82373

Method Description

This method is a qualitative assay that measures transferrin isoform ratios using a combination of immunoaffinity capture and liquid chromatography-mass spectrometry analysis.(Lacey JM, Bergen R, Magera MJ, et al: Rapid determination of transferrin isoforms by immunoaffinity liquid chromatography and electrospray mass spectrometry. Clin Chem. 2001; Mar;47(3):513-518; Helander A, Wielders J, Anton R, et al. Standardisation and use of the alcohol biomarker carbohydrate-deficient transferrin [CDT], Clin Chim Acta. 2017;467:15-20 doi:10.1016/j.cca.2017.03.018)

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Method Name

Affinity Chromatography/Mass Spectrometry (MS)

Forms

If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.