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HelpOrder Code LAB1325 IgG Subclasses, Serum
Additional Codes
| Mayo Test ID |
|---|
| IGGS |
Reporting Name
IgG Subclasses, SUseful For
Second-order testing for evaluation of patients with clinical signs and symptoms of humoral immunodeficiency or combined immunodeficiency (cellular and humoral)
Specimen Type
SerumOrdering Guidance
If testing for immunoglobulin subclass IgG4-related disease, the most appropriate test to order is IGGS4 / IgG4, Immunoglobulin Subclasses, Serum.
Specimen Required
Patient Preparation: Fasting preferred but not required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
See Specimen Required
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Ambient | 14 days | ||
| Frozen | 14 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | OK |
Reference Values
TOTAL IgG
0-<5 months: 100-334 mg/dL
5-<9 months: 164-588 mg/dL
9-<15 months: 246-904 mg/dL
15-<24 months: 313-1,170 mg/dL
2-<4 years: 295-1,156 mg/dL
4-<7 years: 386-1,470 mg/dL
7-<10 years: 462-1,682 mg/dL
10-<13 years: 503-1,719 mg/dL
13-<16 years: 509-1,580 mg/dL
16-<18 years: 487-1,327 mg/dL
≥18 years: 767-1,590 mg/dL
IgG1
0-<5 months: 56-215 mg/dL
5-<9 months: 102-369 mg/dL
9-<15 months: 160-562 mg/dL
15-<24 months: 209-724 mg/dL
2-<4 years: 158-721 mg/dL
4-<7 years: 209-902 mg/dL
7-<10 years: 253-1,019 mg/dL
10-<13 years: 280-1,030 mg/dL
13-<16 years: 289-934 mg/dL
16-<18 years: 283-772 mg/dL
≥18 years: 341-894 mg/dL
IgG2
0-<5 months: ≤82 mg/dL
5-<9 months: ≤89 mg/dL
9-<15 months: 24-98 mg/dL
15-<24 months: 35-105 mg/dL
2-<4 years: 39-176 mg/dL
4-<7 years: 44-316 mg/dL
7-<10 years: 54-435 mg/dL
10-<13 years: 66-502 mg/dL
13-<16 years: 82-516 mg/dL
16-<18 years: 98-486 mg/dL
≥18 years: 171-632 mg/dL
IgG3
0-<5 months: 7.6-82.3 mg/dL
5-<9 months: 11.9-74.0 mg/dL
9-<15 months: 17.3-63.7 mg/dL
15-<24 months: 21.9-55.0 mg/dL
2-<4 years: 17.0-84.7 mg/dL
4-<7 years: 10.8-94.9 mg/dL
7-<10 years: 8.5-102.6 mg/dL
10-<13 years: 11.5-105.3 mg/dL
13-<16 years: 20.0-103.2 mg/dL
16-<18 years: 31.3-97.6 mg/dL
≥18 years: 18.4-106.0 mg/dL
IgG4
0-<5 months: ≤19.8 mg/dL
5-<9 months: ≤20.8 mg/dL
9-<15 months: ≤22.0 mg/dL
15-<24 months: ≤23.0 mg/dL
2-<4 years: ≤49.1 mg/dL
4-<7 years: ≤81.9 mg/dL
7-<10 years: 1.0-108.7 mg/dL
10-<13 years: 1.0-121.9 mg/dL
13-<16 years: ≤121.7 mg/dL
16-<18 years: < or=111.0 mg/dL
≥18 years: 2.4-121.0 mg/dL
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Day(s) Performed
Monday through Friday
Method Name
Turbidimetry
CPT Code Information
82784
82787 x 4
Method Description
The determination of the soluble antigen concentration by turbidimetric methods involves the reaction with specific antiserum to form insoluble complexes. When light is passed through the suspension formed a portion of the light is transmitted and focused onto a photodiode by an optical lens system. The amount of transmitted light is indirectly proportional to the specific protein concentration in the test sample.
Concentrations are automatically calculated by reference to a calibrations curve stored within the instrument.(Package inserts: Optilite IgG Kit. The Binding Site Group, Ltd: ver.11, 08/2015; Optilite IgG1. The Binding Site Group, Ltd: ver.23, 07/2019; Optilite IgG2. The Binding Site Group, Ltd: ver.23, 07/2019; Optilite IgG3. The Binding Site Group, Ltd: ver.8, 12/2014; Optilite IgG4. The Binding Site Group, Ltd: ver.23, 07/2019)
Testing Algorithm
Testing includes total IgG as well as the 4 subclasses of IgG.
For more information see Celiac Disease Diagnostic Testing Algorithm
Special Instructions
Forms
If not ordering electronically, complete, print, and send General Request (T239)