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Order Code LACS1 Lactate, Plasma


Ordering Guidance


This test does not measure D-lactate, an uncommon, often undiagnosed cause of lactic acidosis. If D-lactate testing is needed, order DLAC / D-Lactate, Plasma.



Necessary Information


Patient's age and sex are required.



Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Gray top (potassium oxalate/sodium fluoride)

Submission Container/Tube: Plastic vial

Specimen Volume: 0.625 mL Plasma

Collection Instructions:

1. Draw at least 1 mL whole blood in a 2-mL collection tube or at least 2 mL whole blood in a 4-mL collection tube.

2. Centrifuge and aliquot plasma into a plastic vial.


Useful For

Diagnosing and monitoring patients with lactic acidosis

 

Screening high-risk patients for sepsis or septic shock

Method Name

Enzymatic Colorimetric

Reporting Name

Lactate, P

Specimen Type

Plasma NaFl-KOx

Specimen Minimum Volume

Plasma: 0.25 mL

Specimen Stability Information

Specimen Type Temperature Time
Plasma NaFl-KOx Refrigerated (preferred) 14 days
  Ambient  8 hours

Reject Due To

Gross hemolysis Reject

Reference Values

0-2 months: ≤3.3 mmol/L

3-24 months: ≤3.1 mmol/L

25 months-17 years: ≤2.2 mmol/L

> or  18 years: 0.5-2.0 mmol/L*

 

*Further information regarding the adult clinical action limit is available:

Townsend SR, Phillips GS, Duseja R, et al. Effects of compliance with the early management bundle (SEP-1) on mortality changes among medicare beneficiaries with sepsis: A propensity score matched cohort study. Chest. 2022;161(2):392-406. doi:10.1016/j.chest.2021.07.2167

Method Description

Lactate concentration is determined using an enzymatic colorimetric method. L-lactate is oxidized to pyruvate by the specific enzyme lactate oxidase. Peroxidase generates a colored dye using the hydrogen peroxide generated in the first reaction. The intensity of the color formed is directly proportional to the L-lactate concentration. Concentration is determined by measuring the increase in absorbance.(Package insert: Lactate. Roche Gen.2 Reagent; V15, 08/2024)

Day(s) Performed

Monday through Sunday

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

83605

LOINC Code Information

Test ID Test Order Name Order LOINC Value
LACS1 Lactate, P 2524-7

 

Result ID Test Result Name Result LOINC Value
LACS1 Lactate, P 2524-7