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HelpOrder Code NAACD N-Acetylaspartic Acid, Canavan Disease, Random, Urine
Necessary Information
1. Patient's age and sex are required.
2. Include family history, clinical condition (asymptomatic or acute episode), diet, and drug therapy information
Specimen Required
Supplies: Urine Tubes, 10 mL (T068)
Container/Tube: Plastic, 10-mL urine tube
Specimen Volume: 10 mL
Pediatric: If insufficient collection volume, submit as much specimen as possible in a single container; the laboratory will determine if volume is sufficient for testing.
Collection Instructions:
1. Collect a random urine specimen (first morning void preferred).
2. No preservative.
Forms
Useful For
Diagnosis and monitoring of individuals with Canavan disease
Follow-up quantitation of abnormal organic acid elevations of N-acetylaspartic acid
Special Instructions
Method Name
Gas Chromatography Mass Spectrometry (GC-MS)
Reporting Name
N-acetylaspartic acid, USpecimen Type
UrineSpecimen Minimum Volume
3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Frozen (preferred) | 90 days | |
| Refrigerated | 90 days | ||
| Ambient | 14 days |
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Reference Values
≤50.00 mmol/mol creatinine
Method Description
Urine volumes equivalent to 0.25 to 0.50 mg of creatinine are spiked with the mixture of labeled internal standards, allowed to equilibrate, acidified, and then extracted. After evaporation, the dry residue is derivatized to butyl esters. Specimens are analyzed by capillary gas chromatography mass spectrometry selected ion monitoring using ammonia chemical ionization and a stable isotope dilution method.(Unpublished Mayo method)
Day(s) Performed
Monday
Performing Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
83921