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Order Code RA1U Alpha-1-Microglobulin, Random, Urine


Specimen Required


Container/Tube: Plastic, 5-mL tube

Specimen Volume: 5 mL

Collection Instructions:

1. Collect a random urine specimen.

2. No preservative.


Useful For

Assessment of renal tubular injury or dysfunction using random urine specimens

 

Screening for tubular abnormalities

 

Detecting chronic asymptomatic renal tubular dysfunction (2)

Profile Information

Test ID Reporting Name Available Separately Always Performed
AIMR Alpha-1-Microglobulin, Random, U No Yes
CRETR Creatinine, Random, U Yes, (Order RCTUR) Yes

Method Name

AIMR: Immunonephelometry

CRETR: Enzymatic Colorimetric Assay

Reporting Name

Alpha-1-Microglobulin, Random, U

Specimen Type

Urine

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Refrigerated (preferred) 7 days
  Frozen  7 days

Reject Due To

  All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Reference Values

ALPHA 1- MICROGLOBULIN/CREATININE RATIO:

≥18 years: <35 mg/g creatinine

Reference values have not been established for patients younger than 18 years of age.

 

CREATININE:

≥18 years old: 16-326 mg/dL

Reference values have not been established for patients younger than 18 years of age.

Method Description

Alpha-1-Microglobulin:

In an immunochemical reaction, alpha-1-microglobulin present in the urine sample forms immune complexes with anti-alpha-1-microglobulin-specific antibodies. These complexes scatter a beam of light passed through the sample. The intensity of the scattered light is proportional to the concentration of alpha-1-microglobulin in the sample. The result is evaluated by comparison with a standard of known concentration.(Package insert: N Alpha-1-microglobulin. Siemens; V5, 08/2018)

 

Creatinine:

Creatinine is performed by the enzymatic method, which is based on the determination of sarcosine from creatinine with the aid of creatininase, creatinase, and sarcosine oxidase. The liberated hydrogen peroxide is measured via a modified Trinder reaction using a colorimetric indicator. Optimization of the buffer system and the colorimetric indicator enables the creatinine concentration to be quantified both precisely and specifically.(Package insert: Creatinine plus ver 2. Roche Diagnostics; V16.0, 02/2022)

Day(s) Performed

Monday, Wednesday and Friday

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

83883

82570

Forms

If not ordering electronically, complete, print, and send a Renal Diagnostics Test Request (T830) with the specimen.