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Order Code 11_IS Factor XI Inhibitor Screen, Plasma

Method Name

Only orderable as part of a profile. For more information see:

11INE / Factor XI Inhibitor Evaluation, Plasma

ALBLD / Bleeding Diathesis Profile, Limited, Plasma

APROL / Prolonged Clot Time Profile, Plasma

 

Optical Clot-Based

Reporting Name

Factor XI Inhib Scrn

Specimen Type

Plasma Na Cit

Specimen Minimum Volume

2 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma Na Cit Frozen 14 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Reference Values

Only orderable as part of a profile. For more information see:

11INE / Factor XI Inhibitor Evaluation, Plasma

ALBLD / Bleeding Diathesis Profile, Limited, Plasma

APROL / Prolonged Clot Time Profile, Plasma

 

Negative

Day(s) Performed

Monday through Friday

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

85335


Ordering Guidance


 



Specimen Required


Only orderable as part of a profile. For more information see:

11INE / Factor XI Inhibitor Evaluation, Plasma

ALBLD / Bleeding Diathesis Profile, Limited, Plasma

APROL / Prolonged Clot Time Profile, Plasma

 

For more information see Coagulation Guidelines for Specimen Handling and Processing.


Useful For

Detecting the presence of a specific factor inhibitor directed against coagulation factor XI

Method Description

The factor XI inhibitor screen is performed on the Instrumentation Laboratory ACL TOP. The assay consists of measuring the factor XI activity (activated partial thromboplastin time based assay) before and after incubation of a mixture of normal plasma and patient's plasma for 1 hour at 37° C. Interpretation of the presence or absence of the indication of a factor XI inhibitor is determined by comparing the factor XI activity results and the calculated expected values.(Owen CA Jr, Bowie EJW, Thompson JH Jr. The Diagnosis of Bleeding Disorders. 2nd ed. Little Brown and Company; 1975:143-145; Meijer P, Verbruggen HW, Spannagi M. Chapter 33: Clotting factors and inhibitors: Assays and Interpretation. In: Kottke-Marchant K, ed. Laboratory Hematology Practice. Wiley Blackwell Publishing; 2012:435-446)