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Order Code BA48F Bile Acids, Bowel Dysfunction, 48 Hour, Feces

Useful For

Aids to evaluate patients suspected of having irritable bowel syndrome-diarrhea (IBS-D) symptoms due to bile acid malabsorption

Reporting Name

Bile Acids, Bowel Dysfunc, 48 Hr, F

Specimen Type

Fecal


Ordering Guidance


This test is for evaluation of bowel dysfunction.

 

For evaluation of hepatobiliary dysfunction, order BILEA / Bile Acids, Total, Serum.

For evaluation of patients treated with urso or cholate, order BAFS / Bile Acids, Fractionated and Total, Serum.

For evaluation of inborn errors of metabolism, order BAIPD / Bile Acids for Peroxisomal Disorders, Serum.



Specimen Required


Patient Preparation:

For 3 days prior to and during the collection period:

1. Patient should be on a fat-controlled diet (100-150 g fat per day)

2. No laxatives (particularly mineral oil and castor oil)

3. No synthetic fat substitutes (eg, Olestra) or fat-blocking nutritional supplements

Supplies: Stool Containers - 24, 48, 72 Hours Kit (T291)

Collection Container/Tube: Stool container (T291); complies with shipping requirements, do not use other containers

Specimen Volume: Entire 48-hour collection

Collection Instructions:

1. Do not use other containers.

2. All containers must be sent together.

3. The entire collection must contain at least 5 g of feces.

4. The number of containers sent should be indicated on the labels (1 of 4, for example).

Additional Information:

1. Patient may store sample at refrigerate temperature during collection period.

2. Barium interferes with test procedure; a waiting period of 48 hours before stool collection analysis is recommended.


Specimen Minimum Volume

5 g

Specimen Stability Information

Specimen Type Temperature Time Special Container
Fecal Frozen 30 days

Reject Due To

All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Reference Values

≥ to 18 years:

Sum of cholic acid and chenodeoxycholic acid ≤9.7%

Total bile acids ≤2619 mcmoles/48 hours

 

Reference values have not been established for patients who are <18 years of age

Method Description

Fractionated fecal bile acids are quantified in a 48-hour fecal collection during which a high-fat intake diet was followed. Samples are analyzed on a tandem mass spectrometer.(Unpublished Mayo method)

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

82542

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Forms

If not ordering electronically, complete, print, and send a Gastroenterology and Hepatology Test Request (T728) with the specimen.

Day(s) Performed

Wednesday