Home
HelpOrder Code CLOBZ Clobazam and Metabolite, Serum
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Red top (serum gel/SST are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions:
1. Collect blood immediately before next scheduled dose.
2. Within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.
Additional Information: Trough specimens are recommended as therapeutic ranges are based on specimens collected at trough (ie, immediately before the next dose).
Useful For
Monitoring clobazam therapy
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Reporting Name
Clobazam and metabolite, SSpecimen Type
Serum RedSpecimen Minimum Volume
0.35 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum Red | Refrigerated (preferred) | 28 days | |
| Ambient | 28 days | ||
| Frozen | 28 days |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Reference Values
Clobazam
Therapeutic Range: 30-300 ng/mL
N-desmethylclobazam (Norclobazam)
Therapeutic Range: 300-3,000 ng/mL
Method Description
Methodology involves a simple deproteinization using acetonitrile, followed by dilution, and analysis by liquid chromatography tandem mass spectrometry.(Unpublished Mayo method)
Day(s) Performed
Monday through Friday
Performing Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
80339 (G0480 if appropriate)
Forms
If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.