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HelpOrder Code CMMPS Cobalamin, Methionine, and Methylmalonic Acid Pathways, Serum
Necessary Information
Patient's age and sex are required.
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Within 4 hours of collection, centrifuge and aliquot serum into plastic vial.
Forms
1. Biochemical Genetics Patient Information (T602)
2. If not ordering electronically, complete, print, and send a Biochemical Genetics Test Request (T798) with the specimen.
Useful For
Screening and monitoring patients suspected of or confirmed with an inherited disorder of methionine, cobalamin, or propionate metabolism using serum specimens
Evaluating individuals with suspected deficiency of vitamin B12
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Reporting Name
CMMP, SSpecimen Type
SerumSpecimen Minimum Volume
0.3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 28 days |
| Frozen | 309 days | |
| Ambient | 28 days |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Reference Values
|
Age |
Total homocysteine |
Methylmalonic acid (nmol/mL) |
2-Methylcitric |
Total cysteine |
Methionine (nmol/mL) |
Cystathionine |
|||
|
Female |
Male |
Female |
Male |
||||||
|
0-11 months |
3.1-8.3 |
3.2-9.7 |
0.08-0.32 |
0.02-0.35 |
142.8-258.8 |
14.7-43.1 |
14.5-42.3 |
0.07-0.38 |
|
|
12-23 months |
3.2-8.3 |
3.3-9.6 |
0.08-0.31 |
0.02-0.35 |
143.7-258.7 |
14.7-43.1 |
14.5-42.2 |
0.07-0.38 |
|
|
24-35 months |
3.2-8.2 |
3.3-9.6 |
0.08-0.31 |
0.02-0.35 |
144.8-258.6 |
14.7-43.0 |
14.5-42.1 |
0.07-0.38 |
|
|
3 years |
3.2-8.2 |
3.3-9.6 |
0.08-0.31 |
0.02-0.35 |
146.0-258.5 |
14.7-43.0 |
14.5-42.0 |
0.07-0.38 |
|
|
4 years |
3.3-8.2 |
3.4-9.5 |
0.08-0.30 |
0.02-0.35 |
148.2-258.4 |
14.7-42.8 |
14.5-41.8 |
0.07-0.38 |
|
|
5 years |
3.4-8.1 |
3.5-9.4 |
0.08-0.30 |
0.02-0.35 |
150.6-258.3 |
14.8-42.7 |
14.5-41.6 |
0.07-0.38 |
|
|
6 years |
3.5-8.1 |
3.6-9.4 |
0.08-0.29 |
0.02-0.35 |
153.2-258.3 |
14.8-42.5 |
14.5-41.4 |
0.07-0.38 |
|
|
7 years |
3.5-8.1 |
3.7-9.4 |
0.08-0.29 |
0.02-0.35 |
155.8-258.4 |
14.8-42.2 |
14.5-41.1 |
0.07-0.38 |
|
|
8 years |
3.6-8.2 |
3.8-9.3 |
0.08-0.28 |
0.02-0.35 |
158.5-258.7 |
14.9-42.0 |
14.6-40.9 |
0.07-0.37 |
|
|
9 years |
3.7-8.2 |
3.9-9.4 |
0.09-0.28 |
0.02-0.35 |
161.0-259.1 |
14.9-41.7 |
14.6-40.7 |
0.07-0.37 |
|
|
10 years |
3.8-8.3 |
4.1-9.4 |
0.09-0.28 |
0.02-0.35 |
163.5-259.7 |
15.0-41.4 |
14.7-40.6 |
0.07-0.37 |
|
|
11 years |
3.9-8.4 |
4.3-9.4 |
0.09-0.28 |
0.02-0.35 |
165.9-260.5 |
15.1-41.0 |
14.8-40.4 |
0.07-0.37 |
|
|
12 years |
3.9-8.6 |
4.4-9.5 |
0.09-0.27 |
0.02-0.35 |
168.4-261.4 |
15.1-40.7 |
14.9-40.3 |
0.07-0.37 |
|
|
13 years |
4.0-8.7 |
4.6-9.6 |
0.09-0.27 |
0.02-0.35 |
170.9-262.4 |
15.2-40.3 |
15.1-40.1 |
0.07-0.36 |
|
|
14 years |
4.1-8.8 |
4.8-9.7 |
0.09-0.27 |
0.02-0.35 |
173.6-263.6 |
15.3-39.9 |
15.3-40.0 |
0.07-0.36 |
|
|
15 years |
4.2-8.9 |
5.0-9.8 |
0.09-0.27 |
0.02-0.35 |
176.4-264.7 |
15.4-39.5 |
15.5-39.9 |
0.07-0.36 |
|
|
16 years |
4.2-9.1 |
5.2-9.9 |
0.09-0.27 |
0.02-0.35 |
179.3-265.9 |
15.5-39.1 |
15.8-39.7 |
0.07-0.35 |
|
|
17 years |
4.3-9.2 |
5.4-10.0 |
0.09-0.27 |
0.02-0.35 |
182.2-267.1 |
15.6-38.7 |
16.1-39.6 |
0.07-0.35 |
|
|
18 years |
4.3-9.3 |
5.6-10.1 |
0.08-0.27 |
0.02-0.35 |
184.9-268.3 |
15.7-38.2 |
16.4-39.4 |
0.07-0.35 |
|
|
19 years |
4.4-9.5 |
5.7-10.3 |
0.08-0.26 |
0.02-0.35 |
187.4-269.4 |
15.7-37.8 |
16.7-39.3 |
0.07-0.34 |
|
|
20 years |
4.4-9.6 |
5.9-10.5 |
0.08-0.26 |
0.02-0.35 |
189.5-270.5 |
15.8-37.3 |
17.0-39.1 |
0.07-0.34 |
|
|
21 years |
4.4-9.8 |
6.0-10.6 |
0.08-0.26 |
0.02-0.35 |
191.2-271.7 |
15.9-36.8 |
17.3-38.9 |
0.07-0.33 |
|
|
22 years |
4.4-9.9 |
6.1-10.8 |
0.08-0.27 |
0.02-0.35 |
192.5-272.8 |
15.9-36.3 |
17.6-38.7 |
0.07-0.33 |
|
|
23 years |
4.4-10.1 |
6.2-11.0 |
0.08-0.27 |
0.02-0.35 |
193.5-274.1 |
15.9-35.8 |
17.9-38.5 |
0.07-0.33 |
|
|
24 years |
4.4-10.3 |
6.2-11.1 |
0.08-0.27 |
0.02-0.35 |
194.2-275.4 |
15.9-35.3 |
18.1-38.3 |
0.07-0.32 |
|
|
25 years |
4.4-10.4 |
6.3-11.3 |
0.08-0.28 |
0.02-0.35 |
194.8-277.0 |
15.9-34.8 |
18.2-38.1 |
0.07-0.32 |
|
|
26 years |
4.4-10.6 |
6.3-11.4 |
0.08-0.28 |
0.02-0.35 |
195.3-278.6 |
15.9-34.3 |
18.4-37.9 |
0.07-0.32 |
|
|
27 years |
4.3-10.8 |
6.4-11.6 |
0.08-0.28 |
0.02-0.35 |
196.0-280.5 |
16.0-33.8 |
18.5-37.7 |
0.07-0.31 |
|
|
28 years |
4.3-11.0 |
6.4-11.7 |
0.08-0.29 |
0.02-0.35 |
196.7-282.4 |
16.0-33.4 |
18.7-37.5 |
0.07-0.31 |
|
|
29 years |
4.3-11.2 |
6.4-11.8 |
0.08-0.29 |
0.02-0.35 |
197.7-284.3 |
16.0-33.0 |
18.8-37.3 |
0.07-0.31 |
|
|
30 years |
4.3-11.4 |
6.4-11.9 |
0.08-0.30 |
0.02-0.35 |
198.8-286.3 |
16.1- 32.6 |
18.9-37.1 |
0.07-0.30 |
|
|
31 years |
4.4-11.6 |
6.4-12.1 |
0.08-0.30 |
0.02-0.35 |
200.2-288.2 |
16.1-32.2 |
19.0-36.9 |
0.07-0.30 |
|
|
32 years |
4.4-11.8 |
6.4-12.2 |
0.08-0.31 |
0.02-0.35 |
201.7-290.0 |
16.1-31.8 |
19.1-36.7 |
0.07-0.30 |
|
|
33 years |
4.4-11.9 |
6.4-12.3 |
0.08-0.31 |
0.02-0.35 |
203.4-291.5 |
16.1-31.5 |
19.2-36.5 |
0.07-0.29 |
|
|
34 years |
4.5-12.1 |
6.4-12.4 |
0.08-0.31 |
0.02-0.35 |
205.2-292.9 |
16.1-31.2 |
19.3-36.3 |
0.07-0.29 |
|
|
35 years |
4.5-12.2 |
6.4-12.6 |
0.08-0.32 |
0.02-0.35 |
207.2-294.1 |
16.1-30.8 |
19.4-36.1 |
0.07-0.28 |
|
|
36 years |
4.6-12.4 |
6.4-12.8 |
0.08-0.32 |
0.02-0.35 |
209.3-295.1 |
16.1-30.5 |
19.5-35.9 |
0.07-0.28 |
|
|
37 years |
4.6-12.5 |
6.4-12.9 |
0.08-0.33 |
0.02-0.35 |
211.5-296.0 |
16.1-30.2 |
19.6-35.6 |
0.07-0.27 |
|
|
38 years |
4.7-12.7 |
6.4-13.1 |
0.08-0.33 |
0.02-0.35 |
213.8-296.9 |
16.1-29.9 |
19.7-35.4 |
0.07-0.27 |
|
|
39 years |
4.7-12.8 |
6.4-13.2 |
0.08-0.34 |
0.02-0.35 |
216.3-297.7 |
16.1-29.7 |
19.8-35.2 |
0.07-0.27 |
|
|
40 years |
4.8-13.0 |
6.5-13.4 |
0.08-0.34 |
0.02-0.35 |
218.9-298.7 |
16.1-29.4 |
19.9-35.0 |
0.07-0.27 |
|
|
41 years |
4.8-13.2 |
6.5-13.5 |
0.08-0.35 |
0.02-0.35 |
221.6-299.7 |
16.1-29.2 |
20.0-34.8 |
0.07-0.27 |
|
|
42 years |
4.8-13.4 |
6.5-13.7 |
0.08-0.36 |
0.02-0.35 |
224.3-300.8 |
16.2-29.0 |
20.1-34.6 |
0.07-0.26 |
|
|
43 years |
4.9-13.5 |
6.6-13.9 |
0.08-0.36 |
0.02-0.35 |
227.0-302.0 |
16.2-28.8 |
20.2-34.4 |
0.07-0.26 |
|
|
44 years |
4.9-13.7 |
6.6-14.0 |
0.08-0.37 |
0.02-0.35 |
229.8-303.5 |
16.3-28.6 |
20.3-34.2 |
0.07-0.26 |
|
|
45 years |
4.9-13.9 |
6.6-14.2 |
0.08-0.38 |
0.02-0.35 |
232.6-305.2 |
16.3-28.5 |
20.3-34.0 |
0.07-0.26 |
|
|
46 years |
4.9-14.0 |
6.7-14.4 |
0.08-0.38 |
0.02-0.35 |
235.3-307.3 |
16.4-28.4 |
20.4-33.8 |
0.07-0.26 |
|
|
47 years |
4.9-14.2 |
6.7-14.5 |
0.08-0.39 |
0.02-0.35 |
238.0-309.7 |
16.4-28.2 |
20.4-33.6 |
0.07-0.26 |
|
|
48 years |
5.0-14.3 |
6.8-14.7 |
0.08-0.39 |
0.02-0.35 |
240.8-312.6 |
16.5-28.1 |
20.5-33.3 |
0.07-0.26 |
|
|
49 years |
5.0-14.4 |
6.8-14.9 |
0.08-0.40 |
0.02-0.35 |
243.5-315.9 |
16.5-28.0 |
20.5-33.1 |
0.07-0.26 |
|
|
50 years |
5.0-14.5 |
6.8-15.0 |
0.08-0.40 |
0.02-0.35 |
246.2-319.7 |
16.5-27.9 |
20.6-32.8 |
0.07-0.26 |
|
|
51 years |
5.1-14.6 |
6.8-15.2 |
0.08-0.41 |
0.02-0.35 |
248.9-323.8 |
16.5-27.8 |
20.6-32.5 |
0.07-0.26 |
|
|
52 years |
5.1-14.7 |
6.9-15.4 |
0.08-0.41 |
0.02-0.35 |
251.5-328.1 |
16.5-27.6 |
20.7-32.3 |
0.07-0.26 |
|
|
53 years |
5.1-14.8 |
6.9-15.5 |
0.08-0.42 |
0.02-0.35 |
254.0-332.4 |
16.5-27.5 |
20.8-32.1 |
0.07-0.26 |
|
|
54 years |
5.2-14.9 |
6.9-15.6 |
0.08-0.42 |
0.02-0.35 |
256.4-336.5 |
16.5-27.4 |
21.0-31.9 |
0.07-0.25 |
|
|
55 years |
5.2-15.0 |
6.9-15.7 |
0.08-0.43 |
0.02-0.35 |
258.6-340.2 |
16.5-27.3 |
21.1-31.7 |
0.07-0.25 |
|
|
56 years |
5.3-15.0 |
6.9-15.8 |
0.08-0.43 |
0.02-0.35 |
260.6-343.6 |
16.6-27.2 |
21.2-31.5 |
0.07-0.25 |
|
|
57 years |
5.3-15.1 |
6.9-15.9 |
0.08-0.44 |
0.02-0.35 |
262.5-346.5 |
16.6-27.1 |
21.2-31.3 |
0.07-0.25 |
|
|
58 years |
5.3-15.2 |
6.9-16.0 |
0.08-0.44 |
0.02-0.35 |
264.3-349.0 |
16.6-27.1 |
21.3-31.0 |
0.07-0.25 |
|
|
59 years |
5.4-15.2 |
6.9-16.0 |
0.08-0.44 |
0.02-0.35 |
266.2-351.1 |
16.7-27.1 |
21.3-30.8 |
0.07-0.25 |
|
|
60 years |
5.4-15.3 |
6.9-16.1 |
0.08-0.45 |
0.02-0.35 |
268.3-353.1 |
16.8-27.1 |
21.3-30.6 |
0.07-0.25 |
|
|
61 years |
5.4-15.4 |
7.0-16.2 |
0.09-0.45 |
0.02-0.35 |
270.8-355.1 |
16.9-27.2 |
21.3-30.3 |
0.07-0.25 |
|
|
62 years |
5.5-15.4 |
7.0-16.2 |
0.09-0.46 |
0.02-0.35 |
273.8-357.3 |
17.0-27.2 |
21.2-30.0 |
0.08-0.25 |
|
|
63 years |
5.5-15.5 |
7.0-16.3 |
0.09-0.46 |
0.02-0.35 |
277.5-359.7 |
17.1-27.3 |
21.2-29.8 |
0.08-0.25 |
|
|
64 years |
5.6-15.5 |
7.1-16.3 |
0.09-0.46 |
0.02-0.35 |
281.9-362.3 |
17.2-27.4 |
21.1-29.5 |
0.08-0.25 |
|
|
65 years |
5.6-15.6 |
7.1-16.3 |
0.09-0.47 |
0.02-0.35 |
286.9-365.2 |
17.3-27.6 |
21.1-29.2 |
0.08-0.25 |
|
|
66 years |
5.7-15.6 |
7.1-16.3 |
0.09-0.47 |
0.02-0.35 |
292.4-368.3 |
17.4-27.7 |
21.1-29.0 |
0.08-0.25 |
|
|
67 years |
5.7-15.7 |
7.2-16.3 |
0.09-0.47 |
0.02-0.35 |
298.1-371.6 |
17.5-27.8 |
21.0-28.7 |
0.09-0.25 |
|
|
68 years |
5.8-15.7 |
7.2-16.3 |
0.09-0.47 |
0.02-0.35 |
303.6-374.8 |
17.7-27.9 |
21.0-28.5 |
0.09-0.25 |
|
|
69 years |
5.9-15.7 |
7.2-16.3 |
0.09-0.47 |
0.02-0.35 |
308.7-377.8 |
17.8-28.0 |
21.0-28.4 |
0.09-0.25 |
|
|
70 years |
6.0-15.8 |
7.3-16.3 |
0.09-0.48 |
0.02-0.35 |
313.1-380.7 |
18.0-28.1 |
21.0-28.3 |
0.09-0.25 |
|
|
71 years |
6.1-15.8 |
7.3-16.3 |
0.09-0.48 |
0.02-0.35 |
316.5-383.2 |
18.1-28.2 |
20.9-28.2 |
0.09-0.25 |
|
|
72 years |
6.2-15.8 |
7.3-16.3 |
0.09-0.48 |
0.02-0.35 |
318.9-385.3 |
18.3-28.3 |
20.9-28.0 |
0.09-0.25 |
|
|
73 years |
6.3-15.9 |
7.3-16.3 |
0.09-0.48 |
0.02-0.35 |
320.1-387.0 |
18.5-28.4 |
20.8-27.9 |
0.10-0.26 |
|
|
74 years |
6.4-15.9 |
7.3-16.3 |
0.09-0.48 |
0.02-0.35 |
320.6-388.3 |
18.8-28.5 |
20.8-27.8 |
0.10-0.26 |
|
|
75 years |
6.5-15.9 |
7.3-16.3 |
0.09-0.48 |
0.02-0.35 |
320.3-389.3 |
19.1-28.5 |
20.8-27.7 |
0.10-0.26 |
|
|
76 years |
6.6-15.9 |
7.3-16.3 |
0.09-0.48 |
0.02-0.35 |
319.6-389.9 |
19.3-28.6 |
20.8-27.5 |
0.10-0.26 |
|
|
77 years |
6.7-16.0 |
7.4-16.3 |
0.10-0.48 |
0.02-0.35 |
319.1-390.2 |
19.6-28.6 |
20.9-27.4 |
0.10-0.26 |
|
|
78 years |
6.8-16.0 |
7.4-16.3 |
0.10-0.48 |
0.02-0.35 |
318.5-390.5 |
20.0-28.7 |
20.9-27.2 |
0.11-0.26 |
|
|
79 years |
6.9-16.0 |
7.5-16.3 |
0.10-0.48 |
0.02-0.35 |
317.9-390.6 |
20.3-28.7 |
21.0-27.1 |
0.11-0.26 |
|
|
80 years |
7.0-16.0 |
7.5-16.3 |
0.10-0.48 |
0.02-0.35 |
317.9-390.6 |
20.3-28.7 |
21.0-27.1 |
0.11-0.26 |
|
|
81 years |
7.1-16.0 |
7.7-16.2 |
0.10-0.48 |
0.02-0.35 |
317.9-390.6 |
20.3-28.7 |
21.0-27.1 |
0.11-0.26 |
|
|
82 years |
7.2-16.0 |
7.8-16.2 |
0.10-0.48 |
0.02-0.35 |
317.9-390.6 |
20.3-28.7 |
21.0-27.1 |
0.11-0.26 |
|
|
83 years |
7.2-16.0 |
7.9-16.2 |
0.10-0.48 |
0.02-0.35 |
317.9-390.6 |
20.3-28.7 |
21.0-27.1 |
0.11-0.26 |
|
|
84 years |
7.3-16.0 |
8.0-16.2 |
0.10-0.48 |
0.02-0.35 |
317.9-390.6 |
20.3-28.7 |
21.0-27.1 |
0.11-0.26 |
|
|
85 years |
7.3-16.0 |
8.2-16.2 |
0.10-0.48 |
0.02-0.35 |
317.9-390.6 |
20.3-28.7 |
21.0-27.1 |
0.11-0.26 |
|
|
>85 years |
7.4-16.0 |
8.3-16.2 |
0.10-0.48 |
0.02-0.35 |
317.9-390.6 |
20.3-28.7 |
21.0-27.1 |
0.11-0.26 |
|
An interpretive report will also be provided.
Method Description
Total homocysteine, total cysteine, 2-methylcitric acid, methionine, cystathionine and methylmalonic acid are measured by stabile isotope dilution microflow liquid chromatography tandem mass spectrometry.(Unpublished Mayo method)
Day(s) Performed
Monday, Wednesday, Friday
Performing Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
83090
83918
82136
82542 (if appropriate for government payers)