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Order Code COKEM Cocaine and Metabolites Confirmation, Meconium

Reporting Name

Cocaine and Metabolites, Confirm, M

Useful For

Detecting in utero drug exposure up to 5 months before birth

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Meconium


Ordering Guidance


For chain-of-custody testing, order COKMX / Cocaine and Metabolite Confirmation, Chain of Custody, Meconium.



Specimen Required


Supplies: Stool container, Small (Random), 4 oz (T288)

Container/Tube: Stool container

Specimen Volume: 1 g (approximately 1 teaspoon)

Collection Instructions: Collect entire random meconium specimen.


Specimen Minimum Volume

0.3 g (approximately 1/4 teaspoon)

Specimen Stability Information

Specimen Type Temperature Time
Meconium Frozen (preferred) 21 days
  Refrigerated  21 days
  Ambient  72 hours

Reference Values

Negative

 

Positive results are reported with a quantitative liquid chromatography tandem mass spectrometry (LC-MS/MS) result.

 

Cutoff concentrations for LC-MS/MS testing:

Cocaine: 20 ng/g

Benzoylecgonine: 20 ng/g

Cocaethylene: 20 ng/g

m-Hydroxybenzoylecgonine: 20 ng/g

Day(s) Performed

Monday through Sunday

CPT Code Information

G0480

80353 (if appropriate for select payers)

Method Description

Meconium is mixed with internal standard and extracted with methanol. The methanolic extract is further processed by solid-phase extraction. The extract is analyzed by liquid chromatography tandem mass spectroscopy.(Unpublished Mayo method)

Reject Due To

Grossly bloody Reject; Pink OK
Stool;
Diapers		 Reject

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Forms

If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.