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Order Code COKEP Cocaine and Metabolites, Plasma


Ordering Guidance


Additional drug panels and specific requests are available; call 800-533-1710.



Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Gray top (sodium fluoride/potassium oxalate plasma) (PST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL Plasma

Collection Instructions:

1. Within 2 hours of collection, centrifuge at 4° C and aliquot plasma into a plastic vial.

2. Freeze the specimen.


Useful For

Confirming drug exposure involving stimulants such as cocaine, benzoylecgonine, m-hydroxy-benzoylecgonine, and cocaethylene

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Cocaine and Metabolites, P

Specimen Type

Plasma

Specimen Minimum Volume

Plasma: 0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Plasma Frozen (preferred) 28 days
  Refrigerated  6 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Reference Values

Negative

Positive results are reported with a quantitative result.

 

Cutoff concentrations:

Cocaine: 1.0 ng/mL

Benzoylecgonine: 1.0 ng/mL

Cocaethylene: 1.0 ng/mL

m-Hydroxybenzoylecgonine: 1.0 ng/mL

Method Description

The plasma sample is extracted through protein precipitation, diluted, and then analyzed by liquid chromatography tandem mass spectrometry for the presence of cocaine and metabolites.(Unpublished Mayo method)

Day(s) Performed

Thursday

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

G0480

80353 (if appropriate for select payers)

Clinical Toxicology CPT Code Client Guidance

LOINC Code Information

Test ID Test Order Name Order LOINC Value
COKEP Cocaine and Metabolites, P In Process

 

Result ID Test Result Name Result LOINC Value
624105 Cocaine 3396-9
624106 Benzoylecgonine 3392-8
624107 Cocaethylene 27226-0
624108 m-Hydroxybenzoylecgonine 50593-3