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HelpOrder Code CRUO Chromium Occupational Exposure, Random, Urine
Ordering Guidance
Specimen Required
Patient Preparation: High concentrations of gadolinium and iodine are known to potentially interfere with most inductively coupled plasma mass spectrometry-based metal tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Clean, plastic urine collection container with no metal cap or glued insert
Submission Container/Tube: Plastic, 5-mL tube or a clean, plastic aliquot container with no metal cap or glued insert
Specimen Volume: 3 mL
Collection Instructions:
1. Collect a random urine specimen.
2. See Metals Analysis Specimen Collection and Transport for complete instructions.
Useful For
Screening for occupational exposure to chromium
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| CROM1 | Chromium Occupational Exposure, U | No | Yes |
| CRETR | Creatinine, Random, U | No | Yes |
Special Instructions
Method Name
CROM1: Triple-Quadrupole Inductively Coupled Plasma Mass Spectrometry (ICP-MS/MS)
CRETR: Enzymatic Colorimetric Assay
Reporting Name
Chromium Occupat Exp, Random, USpecimen Type
UrineSpecimen Minimum Volume
2 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Urine | Refrigerated (preferred) | 28 days |
| Frozen | 28 days | |
| Ambient | 14 days |
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Reference Values
CHROMIUM OCCUPATIONAL EXPOSURE
0-17 years: Not established
≥18 years: The American Conference of Governmental Industrial Hygienists (ACGIH) Biological Exposure Index (BEI) for daily occupational exposure to hexavalent chromium in urine is an increase of 10.0 mcg/L between pre-shift and post-shift urine collections. The ACGIH BEI for long- and short-term hexavalent chromium in urine is an end-of-shift concentration above 24.9 mcg/L at the end of the work week.
CREATININE, RANDOM
≥18 years old: 16-326 mg/dL
Reference values have not been established for patients who are younger than 18 years of age.
Method Description
Chromium
The metal of interest is analyzed by triple-quadrupole inductively coupled plasma mass spectrometry.(Unpublished Mayo method)
Creatinine
The enzymatic method is based on the determination of sarcosine from creatinine with the aid of creatininase, creatinase, and sarcosine oxidase. The liberated hydrogen peroxide is measured via a modified Trinder reaction using a colorimetric indicator. Optimization of the buffer system and the colorimetric indicator enables the creatinine concentration to be quantified both precisely and specifically.(Package insert: Creatinine plus ver 2. Roche Diagnostics; V15.0, 03/2019)
Performing Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
82495
82570
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| CRUO | Chromium Occupat Exp, Random, U | 13464-3 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| CRETR | Creatinine, Random, U | 2161-8 |
| 607761 | Chromium Occupational Exposure | 13464-3 |
| 608390 | Chromium Concentration | 5623-4 |
Day(s) Performed
Monday