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Order Code CYSR Cystinuria Profile, Quantitative, Random, Urine

Reporting Name

Cystinuria Profile, QN, Random

Useful For

Biochemical diagnosis of cystinuria using random urine specimens

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Urine


Necessary Information


1. Patient's age is required.

2. Include family history, clinical condition (asymptomatic or acute episode), diet, and drug therapy information



Specimen Required


Supplies: Urine Tubes, 10 mL (T068)

Specimen Volume: 2 mL

Collection Instructions: Collect a random urine specimen.


Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Frozen (preferred) 70 days
  Refrigerated  14 days

Reference Values

Amino Acid

Age groups

<2 months

2-35 months

3-6 years

7-17 years

≥18 years

Arginine

Arg

<250

<147

<81

<42

<65

Ornithine

Orn

<344

<238

<228

<291

<193

Cystine

Cys

<486

<285

<111

<84

<142

Lysine

Lys

<2217

<1321

<814

<463

<295

 

All results reported as nmol/mg creatinine.

Day(s) Performed

Monday through Friday

CPT Code Information

82136

Genetics Test Information

This test provides biochemical diagnosis of cystinuria. It measures cystine, lysine, ornithine, and arginine.

Method Description

Quantitative analysis of amino acids is performed by liquid chromatography tandem mass spectrometry. Patient samples are combined with isotopically labeled internal standard. Following protein precipitation, the supernatant is subjected to hydrophilic-interaction liquid chromatography for the separation of isomers with MS/MS detection of the underivatized amino acids.(Unpublished Mayo method)

Reject Due To

  All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)