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HelpOrder Code DCORT 11-Deoxycortisol, Serum
Useful For
Diagnostic workup of patients with congenital adrenal hyperplasia
Part of metyrapone testing in the workup of suspected secondary or tertiary adrenal insufficiency
Part of metyrapone testing in the differential diagnostic workup of Cushing syndrome
Testing Algorithm
For more information see Steroid Pathways.
Special Instructions
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Reporting Name
11-Deoxycortisol, SSpecimen Type
SerumNecessary Information
Indicate if specimen was collection before or after metyrapone administration.
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions:
1. Morning (8 a.m.) specimen is preferred.
2. Centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
0.4 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 28 days | |
| Ambient | 28 days | ||
| Frozen | 28 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | OK |
| Gross icterus | OK |
Reference Values
≤18 years: <344 ng/dL
>18 years: 10-79 ng/dL
For International System of Units (SI) conversion for Reference Values, see www.mayocliniclabs.com/order-tests/si-unit-conversion.html.
Method Description
The specimen and an internal standard are assayed by liquid chromatography tandem mass spectrometry. The analyte is detected by multiple-reaction monitoring.(Unpublished Mayo method)
Day(s) Performed
Tuesday
Performing Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
82634