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HelpOrder Code F9_IS Factor IX Inhibitor Screen, Plasma
Method Name
Only orderable as a reflex. For more information see:
9INHE / Factor IX Inhibitor Evaluation, Plasma
ALUPP / Lupus Anticoagulant Profile, Plasma
ALBLD / Bleeding Diathesis Profile, Limited, Plasma
APROL / Prolonged Clot Time Profile, Plasma
Optical Clot-Based
Reporting Name
Factor IX Inhib ScrnSpecimen Type
Plasma Na CitSpecimen Minimum Volume
2 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Plasma Na Cit | Frozen | 14 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | Reject |
Reference Values
Only orderable as a reflex. For more information see:
9INHE / Factor IX Inhibitor Evaluation, Plasma
ALUPP / Lupus Anticoagulant Profile, Plasma
ALBLD / Bleeding Diathesis Profile, Limited, Plasma
APROL / Prolonged Clot Time Profile, Plasma
Negative
Day(s) Performed
Monday through Friday
Performing Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
85335
Specimen Required
Only orderable as a reflex. For more information see:
9INHE / Factor IX Inhibitor Evaluation, Plasma
ALUPP / Lupus Anticoagulant Profile, Plasma
ALBLD / Bleeding Diathesis Profile, Limited, Plasma
APROL / Prolonged Clot Time Profile, Plasma
For more information see Coagulation Guidelines for Specimen Handling and Processing.
Useful For
Detecting the presence of a specific factor inhibitor directed against coagulation factor IX
Method Description
The factor IX inhibitor screen is performed on the Instrumentation Laboratory ACL TOP. The assay consists of measuring the factor IX activity (prothrombin time based assay) before and after incubation of a mixture of normal plasma and patient's plasma for 1 hour at 37° C. Interpretation of the presence or absence of the indication of a factor IX inhibitor is determined by comparing the factor IX activity results and the calculated expected values.(Owen CA Jr, Bowie EJW, Thompson JH Jr. The Diagnosis of Bleeding Disorders. 2nd ed. Little Brown and Company; 1975:14-144; Meijer P, Verbruggen and Spannagi M. Chapter 33: Clotting factors and inhibitors: Assays and Interpretation. In: Kottke-Marchant K, ed. Laboratory Hematology Practice. Wiley Blackwell Publishing; 2012:435-446)