Ordering Guidance

This test includes only technical performance of the stain (no pathologist interpretation is performed).

This test provides qualitative results only. For semiquantitative assessment of HER2 as a predictive or prognostic marker in the setting of breast cancer, order HERBA / HER2, Breast, Quantitative Immunohistochemistry, Automated with HER2 FISH Reflex or in the setting of gastric esophageal tissues, order HERGM / HER2, Gastric/Esophageal, Semi-Quantitative Immunohistochemistry, Manual and return Mayo-stained tech only HER2 slide along with hematoxylin and eosin-stained slide, or block and 2 unstained slides.

For immunostain detection of HER2 for diagnostic purposes, order HER2I / HER2 Immunostain, Technical Component Only.

For immunostain detection of HER2 in invasive or metastatic breast primary specimens with interpretation and reflex fluorescence in situ hybridization (FISH) testing, order HERMB / HER2, Breast, Semi-Quantitative Immunohistochemistry, Manual with HER2 FISH Reflex.

For immunostain detection of HER2 in invasive or metastatic gastroesophageal adenocarcinoma primary specimens with interpretation and reflex FISH testing, order HERGM / HER2, Gastric/Esophageal, Semi-Quantitative Immunohistochemistry, Manual.

For immunostain detection of HER2 in invasive or metastatic gastroesophageal adenocarcinoma primary with interpretation but without reflex FISH testing, order HERGN / HER2, Gastric/Esophageal, Semi-Quantitative Immunohistochemistry, Manual, No Reflex.

For immunostain detection of HER2 in invasive or metastatic solid tumors with interpretation and without reflex FISH testing, order HERST / HER, Solid Tumor, Semi-Quantitative Immunohistochemistry, Manual.

For FISH HER2 testing in invasive or metastatic breast primary specimens with interpretation, order H2BR / HER2 Amplification Associated with Breast Cancer, FISH, Tissue.

For FISH HER2 testing in invasive or metastatic primary gastroesophageal specimens with interpretation, order H2GE / HER2 Amplification Associated with Gastroesophageal Cancer, FISH, Tissue.

For FISH HER2 testing in primary or metastatic tumor specimens which are not breast or gastroesophageal primary, order H2MT / HER2 Amplification, Miscellaneous Tumor, FISH, Tissue.

For interpretation and diagnosis of submitted pathology specimens with appropriate additional stains and other ancillary testing, order PATHC / Pathology Consultation.

Additional material may be needed if alternative testing is requested. See the specific specimen requirements for the alternative requested testing.

Shipping Instructions

Attach the green "Attention Pathology" address label (T498) and the pink Immunostain Technical Only label included in the kit to the outside of the transport container.

Specimen Required

Specimen Type: Tissue

Supplies: Immunostain Technical Only Envelope (T693)

Container/Tube: Immunostain Technical Only Envelope

Submit:

-Formalin-fixed, paraffin-embedded tissue block

OR

-2 Unstained, positively charged glass slides (25- x 75- x 1-mm) per test ordered; sections 4-microns thick