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HelpOrder Code HMUCR Heavy Metal/Creatinine Ratio, with Reflex, Random, Urine
Specimen Required
1. For the 48-hour period prior to start of collection, patient should not eat seafood.
2. High concentrations of gadolinium and iodine are known to potentially interfere with most inductively coupled plasma mass spectrometry-based metal tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.
Supplies: Urine Tubes, 10 mL (T068)
Collection Container/Tube: Clean, plastic urine container with no metal cap or glued insert
Submission Container/Tube: Plastic, 10-mL urine tube or clean, plastic aliquot container with no metal cap or glued insert
Specimen Volume: 6 mL
Collection Instructions:
1. Collect a random urine specimen.
2. See Metals Analysis Specimen Collection and Transport for complete instructions.
Useful For
Preferred screening test for detection of arsenic, cadmium, mercury, and lead in random urine specimens
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| ASCU | Arsenic/Creatinine Ratio, U | Yes, (order ASUCR) | Yes |
| CDCU | Cadmium/Creatinine Ratio, U | Yes, (order CDUCR) | Yes |
| HGCU | Mercury/Creatinine Ratio, U | Yes, (order HGUCR) | Yes |
| PBCU | Lead/Creatinine Ratio, U | Yes, (order PBUCR) | Yes |
| CRETR | Creatinine, Random, U | No | Yes |
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| SPAS | Arsenic Speciation, Random, U | Yes | No |
Testing Algorithm
If the total arsenic concentration is 10 mcg/L or greater, then speciation will be performed at an additional charge.
For more information see Porphyria (Acute) Testing Algorithm
Special Instructions
Method Name
ASCU, CDCU, HGCU, PBCU: Triple-Quadrupole Inductively Coupled Plasma Mass Spectrometry (ICP-MS/MS)
CRETR: Enzymatic Colorimetric Assay
Reporting Name
Heavy Metal/Creat Ratio,w/Reflex,USpecimen Type
UrineSpecimen Minimum Volume
3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Refrigerated (preferred) | 7 days | |
| Frozen | 7 days |
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Reference Values
ARSENIC/CREATININE:
0-17 years: Not established
≥18 years: <24 mcg/g creatinine
CADMIUM/CREATININE:
0-17 years: Not established
≥18 years: <0.6 mcg/g creatinine
MERCURY/CREATININE:
0-17 years: Not established
≥18 years: <2 mcg/g creatinine
LEAD/CREATININE:
0-17 years: Not established
≥18 years: <2 mcg/g creatinine
CREATININE:
≥18 years: 16-326 mg/dL
Reference values have not been established for patients who are younger than 18 years.
Method Description
The metal analytes of interest are analyzed by triple-quadrupole inductively coupled plasma mass spectrometry.(Unpublished Mayo method)
Performing Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
82175
82300
83825
83655
82570
Day(s) Performed
Monday through Friday