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HelpOrder Code HMUOE Heavy Metal Occupational Exposure, with Reflex, Random, Urine
Specimen Required
Patient Preparation:
1. For 48 hours before collection, patient should not eat seafood.
2. High concentrations of gadolinium and iodine are known to potentially interfere with most inductively coupled plasma mass spectrometry-based metal tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.
Supplies: Urine Tubes, 10 mL (T068)
Collection Container/Tube: Clean, plastic urine container with no metal cap or glued insert
Submission Container/Tube: Plastic, 10-mL urine tube or clean, plastic aliquot container with no metal cap or glued insert
Specimen Volume: 6 mL
Collection Instructions:
1. Collect a random urine specimen.
2. See Metals Analysis Specimen Collection and Transport for complete instructions.
Useful For
Preferred screening test for detection of arsenic, cadmium, mercury, and lead due to occupational exposure using random urine specimens
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| ASOU | Arsenic Occupational Exposure | Yes, (order ASUOE) | Yes |
| CDOU | Cadmium Occupational Exposure | Yes, (order CDUOE) | Yes |
| HGOU | Mercury Occupational Exposure | Yes, (order HGUOE) | Yes |
| PBOU | Lead Occupational Exposure | Yes, (order PBOUE) | Yes |
| CRETR | Creatinine, Random, U | No | Yes |
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| SPAS | Arsenic Speciation, Random, U | Yes | No |
Testing Algorithm
If arsenic concentration is greater than or equal to 10 mcg/L, then speciation will be performed at an additional charge.
Special Instructions
Method Name
ASOU, CDOU, HGOU, PBOU: Triple-Quadrupole Inductively Coupled Plasma Mass Spectrometry (ICP-MS/MS)
CRETR: Colorimetric
Reporting Name
Heavy Metal Occ Exp w/Reflex, USpecimen Type
UrineSpecimen Minimum Volume
3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Urine | Refrigerated (preferred) | 7 days |
| Frozen | 7 days |
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Reference Values
ARSENIC:
Biological Exposure Indices (BEI): <35 mcg/L at end of work week
CADMIUM:
BEI: <5.0 mcg/g creatinine
MERCURY:
BEI: <35 mcg/g creatinine
LEAD:
BEI: <150 mcg/g creatinine
CREATININE:
<18 years: Not established
≥18 years: 16-326 mg/dL
Method Description
Arsenic. Cadmium, Mercury, Lead:
The metal analytes of interest are analyzed by triple-quadrupole inductively coupled plasma mass spectrometry.(Unpublished Mayo method)
Creatinine:
This enzymatic method is based on the conversion of creatinine with the aid of creatininase, creatinase, and sarcosine oxidase to form glycine, formaldehyde, and hydrogen peroxide. Catalyzed by peroxidase the liberated hydrogen peroxide reacts with 4-aminophenazone and HTIB (2,4,6-triiodo03-hydroxybenzoic acid) to form a quinone imine chromogen. The color intensity of the quinone imine chromogen formed is directly proportional to the creatinine concentration in the reaction mixture.(Package insert: Creatinine plus ver.2. Roche Diagnostics; 07/2024)
Performing Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
82175
82300
83825
83655
82570
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| HMUOE | Heavy Metal Occ Exp w/Reflex, U | 29589-9 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| CRETR | Creatinine, Random, U | 2161-8 |
| 608890 | Arsenic Occupational Exposure | 13463-5 |
| 608892 | Cadmium Occupational Exposure | 13471-8 |
| 608893 | Mercury Occupational Exposure | 13465-0 |
| 608894 | Lead Occupational Exposure | 13466-8 |
| 608891 | Total Arsenic Concentration | 5586-3 |
Day(s) Performed
Monday through Friday