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HelpOrder Code LAB1255 Catecholamine Fractionation, Free, 24 Hour, Urine
Additional Codes
| Mayo Test ID |
|---|
| CATU |
Reporting Name
Catecholamine Fract, Free, UUseful For
An auxiliary test to fractionated plasma and urine metanephrine measurements in the diagnosis of pheochromocytoma and paraganglioma
An auxiliary test to urine vanillylmandelic acid and homovanillic acid determination in the diagnosis and follow-up of patients with neuroblastoma and related tumors
This test is not useful as a first-line test for pheochromocytoma.
Specimen Type
UrineOrdering Guidance
This assay is of greatest value when the specimen is collected during a hypertensive episode.
Do not perform the test on patients withdrawing from legal or illegal drugs known to cause rebound catecholamine release during withdrawal (see Cautions).
This test is not a first-line test for pheochromocytoma. The recommended first-line laboratory tests for pheochromocytoma are PMET / Metanephrines, Fractionated, Free, Plasma; and METAF / Metanephrines, Fractionated, 24 Hour, Urine.
Necessary Information
24-Hour volume (in milliliters) is required.
Specimen Required
Patient Preparation:
1. If medically feasible, discontinue drugs that release or hinder metabolism of epinephrine, norepinephrine, or dopamine for at least 1 week prior to specimen collection (see Cautions for details). If this is not possible for medical reasons, contact the laboratory to discuss whether a shorter drug-withdrawal period may be acceptable.
2. Unless the reason for testing is drug monitoring, the patient should stop any epinephrine, norepinephrine, or dopamine injections or infusions for at least 12 hours prior to specimen collection.
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container: Plastic vial
Specimen Volume: 2 mL
Collection Instructions:
1. Add 25 mL of 50% acetic acid as preservative at start of collection. Use 15 mL of 50% acetic acid for children younger than 5 years old. This preservative is intended to achieve a pH of between approximately 2 and 4.
2. Collect urine for 24 hours.
Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens for multiple collections.
Specimen Minimum Volume
1.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Refrigerated (preferred) | 28 days | |
| Frozen | 28 days |
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Reference Values
Norepinephrine <1 year: <11 mcg/24 h
1 year: 1-17 mcg/24 h
2-3 years: 4-29 mcg/24 h
4-6 years: 8-45 mcg/24 h
7-9 years: 13-65 mcg/24 h
≥10 years: 15-80 mcg/24 h
Epinephrine
<1 year: <2.6 mcg/24 h
1 year: <3.6 mcg/24 h
2-3 years: <6.1 mcg/24 h
4-9 years: 0.2-10.0 mcg/24 h
10-15 years: 0.5-20.0 mcg/24 h
≥16 years: <21 mcg/24 h
Dopamine
<1 year: <86 mcg/24 h
1 year: 10-140 mcg/24 h
2-3 years: 40-260 mcg/24 h
≥4 years: 65-400 mcg/24 h
For International System of Units (SI) conversion for Reference Values, see www.mayocliniclabs.com/order-tests/si-unit-conversion.html.
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Day(s) Performed
Monday through Saturday
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
CPT Code Information
82384
Special Instructions
Method Description
Norepinephrine (NE), epinephrine (E), and dopamine (DA) are derivatized before being adsorbed onto activated alumina, washed with water, and eluted. The eluate is analyzed using liquid chromatography tandem mass spectrometry and quantified using stable isotope-labeled internal standards, d6-NE, d6-E, and d4-DA. Derivatized analytes and internal standards are ionized using electrospray ionization and are detected in the multiple-reaction monitoring mode.(Unpublished Mayo method)
Forms
If not ordering electronically, complete, print, and send an Oncology Test Request (T729) with the specimen.