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Order Code LAB303 Carbamazepine, Total, Serum

Additional Codes

Mayo Test Code:CARTA
EPIC Test Code: LAB303

Useful For

Monitoring therapy

 

Determining compliance

 

Assessing toxicity

Method Name

Homogeneous Microparticle Agglutination Immunoassay

Reporting Name

Carbamazepine, Tot, S

Specimen Type

Serum Red


Ordering Guidance


This test measures carbamazepine only. For assessment of its active metabolite, carbamazepine-10,11-epoxide, which is the predominant form in children, order CARBG / Carbamazepine-10,11-Epoxide, Serum)



Specimen Required


Collection Container/Tube: Red top

Specimen Volume: 0.5 mL

Submission Container/Tube: Plastic vial

Collection Instructions: Centrifuge and aliquot serum into a plastic vial within 2 hours of collection.


Specimen Minimum Volume

0.25 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Red Refrigerated (preferred) 7 days
  Frozen  28 days
  Ambient  48 hours

Reject Due To

Gross hemolysis Reject

Reference Values

Therapeutic: 4.0-12.0 mcg/mL

Critical value: ≥15.0 mcg/mL

Method Description

The ONLINE TDM Carbamazepine Gen.4 assay is a homogeneous microparticle agglutination immunoassay. It is a 2-reagent system used for the detection of carbamazepine in serum. Kinetic interaction of microparticles (KIMS) will be measured using automated analyzers. In this technology biotinylated drug hapten attached to streptavidin-coated latex beads serves as the binding partner to anti-carbamazepine antibody. A competitive reaction to a limited amount of specific anti-carbamazepine antibody takes place between the latex bound hapten and free carbamazepine in the serum sample. A decrease in the apparent signal is proportional to the amount of drug present in the sample.(Package insert: Carbamazepine reagent. Roche Diagnostics; 06/2024)

Day(s) Performed

Monday through Sunday

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

80156 

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CARTA Carbamazepine, Tot, S 3432-2

 

Result ID Test Result Name Result LOINC Value
CARTA Carbamazepine, Tot, S 3432-2

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-Neurology Specialty Testing Client Test Request (T732)

-Therapeutics Test Request (T831)