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HelpOrder Code LAB3851 Cocaine and Metabolite Confirmation, Random, Urine
Additional Codes
Mayo Code: COKEU
Reporting Name
Cocaine and metabolite Conf, UUseful For
Detecting and confirming drug abuse involving cocaine
This test is not intended for employment-related testing.
Specimen Type
UrineOrdering Guidance
1. For situations where chain of custody is required, a Chain-of-Custody Kit (T282) is available. For chain-of-custody testing, order COKEX / Cocaine and Metabolite Confirmation, Chain of Custody, Random, Urine.
2. Additional drug panels and specific requests are available. Call 800-533-1710 or 507-266-5700.
3. If urine creatinine is required or adulteration of the sample is suspected, order ADULT / Adulterants Survey, Random, Urine.
Specimen Required
Supplies: Urine Tubes, 10 mL (T068)
Collection Container/Tube: Plastic urine container
Submission Container/Tube: 10-mL urine tube
Specimen Volume: 10 mL
Collection Instructions:
1. Collect a random urine specimen.
2. No preservative.
Additional Information:
1. No specimen substitutions.
2. STAT requests are not accepted for this test.
Specimen Minimum Volume
5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Urine | Refrigerated (preferred) | 14 days |
| Frozen | 14 days | |
| Ambient | 72 hours |
Reject Due To
| All specimens will be evaluated at Mayo Clinic Laboratories for test suitability. |
Reference Values
Negative (Positive results are reported with a quantitative result.)
Cutoff concentrations by gas chromatography mass spectrometry:
Cocaine: 50 ng/mL
Benzoylecgonine: 50 ng/mL
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Day(s) Performed
Monday, Wednesday, Thursday, Friday
Method Name
Gas Chromatography Mass Spectrometry (GC-MS) Confirmation with Quantitation
CPT Code Information
G0480
80353 (if appropriate for select payers)
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| COKEU | Cocaine and metabolite Conf, U | 53747-2 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 2922 | Cocaine-by GC/MS | 20519-5 |
| 2902 | Benzoylecgonine-by GC/MS | 16226-3 |
| 20671 | Cocaine Interpretation | 69050-3 |
| 28080 | Chain of Custody | 77202-0 |
Method Description
To accommodate the need to confirm specifically the presence of cocaine in urine, Mayo Clinic Laboratories offers a single test to identify cocaine and its principal metabolite, benzoylecgonine, by using gas chromatography mass spectrometry.(Chinn DM, Crouch DJ, Peat MA, et al. Gas chromatography-chemical ionization mass spectrometry of cocaine and its metabolites in biological fluids. J Anal Toxicol 1980;4:37-42; Rosado T, Goncalves A, Margalho C, Barroso M, Gallardo E. Rapid analysis of cocaine and metabolites in urine using microextraction in packed sorbent and GC/MS. Anal Bioanal Chem. 2017;409(8):2051-2063. doi:10.1007/s00216-016-0152-2)
Forms
If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.