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HelpOrder Code LABIL6 Interleukin-6, Serum
Additional Codes
Mayo Test Code: IL6DX
EPIC Test Code: LABIL6
Specimen Required
Collection Container/Tube: Serum gel
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into plastic vial
Useful For
Evaluating patients with suspected chronic inflammatory disorders, such as rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, or inflammatory bowel disease
Evaluating patients with Castleman disease
Evaluating patients with suspected systemic infection
Evaluating patients with suspected localized infection, specifically prosthetic joint infection
Assisting in identifying severe inflammatory response in patients with confirmed COVID-19 illness to aid in determining the risk of intubation with mechanical ventilation, in conjunction with clinical findings and the results of other laboratory testing
Method Name
Immunoenzymatic
Reporting Name
Interleukin-6, SSpecimen Type
SerumSpecimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Frozen | 90 days | ||
| Ambient | 24 hours |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | Reject |
Reference Values
< 6.4 pg/mL
Method Description
The Access Interleukin-6 (IL-6) assay is a simultaneous one-step immunoenzymatic (sandwich) assay. A patient sample is added to a reaction vessel along with the paramagnetic particles coated with mouse monoclonal anti-human IL-6, blocking reagent, and the alkaline phosphatase conjugate.
After incubation in a reaction vessel, materials bound to the solid phase are held in a magnetic field while unbound materials are washed away. Then, the chemiluminescent substrate is added to the vessel and light generated by the reaction is measured with a luminometer. The light production is directly proportional to the concentration of IL-6 in the sample. The amount of analyte in the sample is determined from a stored, multi-point calibration curve.(Instruction manual: Access IL-6 Instructions for Use, Beckman Coulter, Inc; 10/2020)
Day(s) Performed
Monday through Saturday
Performing Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
83529