Order Code LABMECOX Drugs of Abuse Screen 5, Chain of Custody, Meconium
Additional Codes
Mayo Test Code: DSM5X
Useful For
Identifying amphetamines (and methamphetamines), opiates, phencyclidine, as well as metabolites of cocaine and marijuana in meconium specimens
Chain of custody is required whenever the results of testing could be used in a court of law. Its purpose is to protect the rights of the individual contributing the specimen by demonstrating that it was always under the control of personnel involved with testing the specimen; this control implies that the opportunity for specimen tampering would be limited. Since the evidence of illicit drug use during pregnancy can be cause for separating the baby from the mother, a complete chain of custody ensures that the test results are appropriate for legal proceedings.
Additional Tests
Test ID | Reporting Name | Available Separately | Always Performed |
---|---|---|---|
COCH | Chain of Custody Processing | No | Yes |
Reflex Tests
Test ID | Reporting Name | Available Separately | Always Performed |
---|---|---|---|
COKMX | Cocaine and metabolite Conf, CoC, M | Yes | No |
OPTMX | Opiate Confirmation, CoC, M | Yes | No |
PCPMX | Phencyclidine Confirmation, CoC, M | Yes | No |
THCMX | Carboxy-THC Confirmation, CoC, M | Yes | No |
AMPMX | Amphetamines Confirmation, CoC, M | Yes | No |
Testing Algorithm
Testing begins with immunoassay screen. Positive results are confirmed and quantitated by liquid chromatography tandem mass spectrometry at an additional charge.
Reporting Name
Drugs of Abuse Screen 5, CoC, MSpecimen Type
MeconiumSpecimen Required
Container/Tube: Chain of Custody Meconium Kit (T653) includes the specimen containers, seals, and documentation required
Specimen Volume: 1 g (approximately 1 teaspoon)
Collection Instructions: Collect entire random meconium specimen
Additional Information:
1. Specimen that arrives with a broken seal does not meet the chain-of-custody requirements.
2. The laboratory recommends sending chain-of-custody specimens by overnight shipment.
Specimen Minimum Volume
0.45 g (approximately 0.5 teaspoon)
Specimen Stability Information
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Meconium | Frozen (preferred) | 21 days | |
Refrigerated | 21 days | ||
Ambient | 72 hours |
Reject Due To
Grossly bloody | Reject, Pink OK |
Reference Values
Negative
Positive results are reported with a quantitative liquid chromatography tandem mass spectrometry result.
Cutoff concentrations by competitive chemiluminescent immunoassay:
Amphetamines: 100 ng/g
Methamphetamine: 100 ng/g
Benzoylecgonine (cocaine metabolite): 100 ng/g
Opiates: 100 ng/g
Tetrahydrocannabinol carboxylic acid (marijuana metabolite): 20 ng/g
Phencyclidine: 20 ng/g
Method Description
The meconium sample received is screened by competitive chemiluminescent immunoassay by Randox Evidence+ to detect the presence of any of the drugs, or drugs that cross react with amphetamine, methamphetamine, cocaine metabolite, opiates, phencyclidine, and carboxy-tetrahydrocannabinol. Meconium specimens identified as positive by this screen are analyzed using liquid chromatography tandem mass spectroscopy for the specific drug or drug class indicated.(Unpublished Mayo method)
Day(s) Performed
Monday through Saturday
Performing Laboratory
Mayo Clinic Laboratories in RochesterCPT Code Information
80307
80324 (if appropriate)
80359 (if appropriate)
80353 (if appropriate)
80361 (if appropriate)
80365 (if appropriate)
80349 (if appropriate)
83992 (if appropriate)
Method Name
Competitive Chemiluminescent Immunoassay (CIA)
Forms
1. Chain of Custody Request is included in the Chain-of-Custody Kit (T282).
2. If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.