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HelpOrder Code LABTHYGS Thyroglobulin Antibody, Serum
Additional Codes
Mayo Test Code: TGAB
EPIC Test Code: LABTHYGS
Reporting Name
Thyroglobulin Antibody, SUseful For
As an adjunct in the diagnosis of autoimmune thyroid diseases: Hashimoto disease, postpartum thyroiditis, neonatal hypothyroidism, and Graves disease
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
Serum RedOrdering Guidance
For the follow-up of patients with differentiated follicular cell-derived thyroid carcinomas, consider either HTG2 / Thyroglobulin, Tumor Marker, Serum or HTGR / Thyroglobulin, Tumor Marker Reflex, Serum.
The preferred method for confirming Graves disease in atypical cases or under special clinical circumstances is measurement of the pathogenic antithyrotropin receptor antibodies by binding assay or bioassay. Order either THYRO / Thyrotropin Receptor Antibody, Serum or TSI / Thyroid-Stimulating Immunoglobulin, Serum.
Specimen Required
Patient Preparation: For 12 hours before specimen collection, patient should not take multivitamins or dietary supplements (eg, hair, skin, and nail supplements) containing biotin (vitamin B7).
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Container/Tube: Red top (gel tubes/SST are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 0.6 mL serum
Collection Instructions: Within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
Serum: 0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum Red | Refrigerated (preferred) | 7 days |
| Frozen | 30 days | |
| Ambient | 7 days |
Reference Values
<4.0 IU/mL
Reference values apply to all ages.
Day(s) Performed
Monday through Saturday
CPT Code Information
86800
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| TGAB | Thyroglobulin Antibody, S | 56536-6 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| TGAB | Thyroglobulin Antibody, S | 56536-6 |
Method Description
The Access Thyroglobulin Antibody II assay (TgAb) is a sequential 2-step immunoenzymatic (sandwich) assay. A sample is added to a reaction vessel with paramagnetic particles coated with the thyroglobulin protein. The serum TgAb binds to thyroglobulin. After incubation in a reaction vessel, materials bound to the solid phase are held in place by a magnetic field, while unbound materials are washed away. Thyroglobulin-alkaline phosphatase conjugate is added and binds to the TgAb. After a second incubation, materials bound to the solid phase are held in place by a magnetic field, while unbound materials are washed away. Then, chemiluminescent substrate is added to the reaction vessel, and light generated by the reaction is measured with a luminometer.(Package insert: Access Thyroglobulin Antibody II. Beckman Coulter Inc; 04/2020)
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | OK |
| Gross icterus | Reject |
Method Name
Immunoenzymatic Assay
Forms
If not ordering electronically, complete, print, and send General Test Request (T239) with the specimen.