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Order Code LEVE Levetiracetam, Serum

Important Note

AKA KEPPRA

EPIC ORDER CODE: LAB3520

Additional Codes

Mayo Test ID
LEVE

Reporting Name

Levetiracetam, S

Useful For

Monitoring serum concentration of levetiracetam, particularly in patients with kidney disease

 

Assessing compliance with levetiracetam therapy

 

Assessing potential toxicity of levetiracetam

Specimen Type

Serum


Specimen Required


Supplies: Sarstedt Aliquot Tube 5 mL (T914)

Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Draw blood immediately before next scheduled dose.

2. For sustained-release formulations only, draw blood a minimum of 12 hours after last dose.

3. Within 2 hours of collection, centrifuge, and aliquot serum into a plastic vial


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Reference Values

10.0-40.0 mcg/mL

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Day(s) Performed

Monday through Sunday

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

CPT Code Information

80177

Method Description

The serum sample is diluted in acetonitrile containing internal standard. The protein precipitate is centrifuged, and a portion of the supernatant is diluted with mobile phase for detection by a tandem mass spectrometer.(Unpublished Mayo method)

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-Neurology Specialty Testing Client Test Request (T732)

-General Request (T239)

-Therapeutics Test Request (T831)