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HelpOrder Code MNRCU Manganese/Creatinine Ratio, Random, Urine
Specimen Required
Patient Preparation: High concentrations of gadolinium and iodine are known to potentially interfere with most inductively coupled plasma mass spectrometry-based metal tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours
Supplies: Urine Tubes, 10 mL (T068)
Collection Container/Tube: Clean, plastic urine collection container with no metal cap or glued insert
Submission Container/Tube: Plastic, 10-mL urine tube or clean, plastic aliquot container with no metal cap or glued insert
Specimen Volume: 3 mL
Collection Instructions:
1. Collect a random urine specimen.
2. See Metals Analysis Specimen Collection and Transport for complete instructions.
Useful For
Monitoring manganese exposure using random urine specimens
Nutritional monitoring
Clinical trials
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| MNCU | Manganese/Creat Ratio, U | No | Yes |
| CRETR | Creatinine, Random, U | No | Yes |
Special Instructions
Method Name
MNCU: Triple-Quadrupole Inductively Coupled Plasma Mass Spectrometry (ICP-MS/MS)
CRETR: Enzymatic Colorimetric Assay
Reporting Name
Manganese/Creat Ratio, Random, USpecimen Type
UrineSpecimen Minimum Volume
2 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Urine | Refrigerated (preferred) | 28 days |
| Frozen | 28 days | |
| Ambient | 7 days |
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Reference Values
MANGANESE
0-17 years: Not established
≥18 years: <4.0 mcg/g creatinine
CREATININE, RANDOM
0-17 years: Not established
≥18 years old: 16-326 mg/dL
Method Description
Manganese
The metal of interest is analyzed by triple-quadrupole inductively coupled plasma mass spectrometry.(Unpublished Mayo method)
Creatinine
The enzymatic method is based on the determination of sarcosine from creatinine with the aid of creatininase, creatinase, and sarcosine oxidase. The liberated hydrogen peroxide is measured via a modified Trinder reaction using a colorimetric indicator. Optimization of the buffer system and the colorimetric indicator enables the creatinine concentration to be quantified both precisely and specifically.(Package insert: Creatinine plus ver 2. Roche Diagnostics; V15.0, 03/2019)
Day(s) Performed
Monday
Performing Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
82570
83785
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| MNRCU | Manganese/Creat Ratio, Random, U | 27367-2 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| CRETR | Creatinine, Random, U | 2161-8 |
| 614994 | Manganese/Creat Ratio, U | 27367-2 |