Home
HelpOrder Code NIUCR Nickel/Creatinine Ratio, Random, Urine
Ordering Guidance
This test is preferred for the determination of nickel exposure, but serum concentrations can be used to verify an elevated urine concentration. For more information see NIS / Nickel, Serum.
Specimen Required
Patient Preparation: High concentrations of gadolinium and iodine are known to interfere with most metal tests. If gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.
Supplies: Urine Tubes, 10 mL (T068)
Container/Tube: Plastic, 10-mL urine tube or clean, plastic aliquot container with no metal cap or glued insert
Specimen Volume: 3 mL
Collection Instructions:
1. Collect a random urine specimen
2. See Metals Analysis Specimen Collection and Transport for complete instructions.
Useful For
Preferred specimen type for biomonitoring nickel exposure
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| NIUC | Nickel/Creat Ratio, U | No | Yes |
| CRETR | Creatinine, Random, U | No | Yes |
Special Instructions
Method Name
NIUC: Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)
CRETR: Enzymatic Colorimetric Assay
Reporting Name
Nickel/Creat Ratio, Random, USpecimen Type
UrineSpecimen Minimum Volume
1.2 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Urine | Refrigerated (preferred) | 28 days |
| Frozen | 28 days | |
| Ambient | 14 days |
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Reference Values
NICKEL:
0-17 years: Not established
Males ≥18 years: <3.8 mcg/g creatinine
Females ≥18 years: <4.3 mcg/g creatinine
CREATININE:
≥18 years old: 16-326 mg/dL
Reference values have not been established for patients younger than 18 years of age.
Method Description
The metal of interest is analyzed by inductively coupled plasma mass spectrometry.(Unpublished Mayo method)
Day(s) Performed
Thursday
Performing Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
83885
82570