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HelpOrder Code PTHRP Parathyroid Hormone-Related Peptide, Plasma
Reporting Name
PTH-Related PeptideUseful For
Aiding in the evaluation of individuals with hypercalcemia of unknown origin
Aiding in the evaluation of individuals with suspected humoral hypercalcemia of malignancy
The test should not be used to exclude cancer or screen individuals with tumors for humoral hypercalcemia of malignancy.
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
Plasma EDTASpecimen Required
Collection Container/Tube: Ice-cooled, lavender top (EDTA)
Submission Container/Tube: Plastic vial
Specimen Volume: 0.7 mL
Collection Instructions:
1. Centrifuge specimen in a refrigerated centrifuge or in chilled centrifuge cups.
2. Aliquot plasma into plastic vial and freeze.
Specimen Minimum Volume
0.25 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Plasma EDTA | Frozen | 30 days |
Reference Values
≤4.2 pmol/L
Day(s) Performed
Monday through Thursday
CPT Code Information
82397
Method Description
The parathyroid hormone-related peptide (PTHrP) assay is a plate-based chemiluminescent assay utilizing an anti-PTHrP rabbit-polyclonal antibody for capture and an acridinium ester anti-PTHrP goat-polyclonal antibody for detection. The assay targets 1-86 PTHrP.(Ashrafzadeh-Kian S, Bornhorst J, Algeciras-Schimnich A. Development of a PTHrP chemiluminescent immunoassay to assess humoral hypercalcemia of malignancy. Clin Biochem. 2022;105-106:75-80. doi: 10.1016/j.clinbiochem.2022.04.005)
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | OK |
| Gross icterus | OK |
Method Name
Immunochemiluminometric Assay (ICMA)
Forms
If not ordering electronically, complete, print, and send a General Request (T239) with the specimen.