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Order Code RBR Retinol-Binding Protein, Random, Urine


Specimen Required


Container/Tube: Plastic, 5-mL tube

Specimen Volume: 5 mL

Collection Instructions:

1. Collect a random urine specimen.

2. No preservative.


Useful For

Assessing renal tubular injury or dysfunction using random urine collections

 

Screening for other tubular abnormalities

 

Detecting chronic asymptomatic renal tubular dysfunction.(2)

Profile Information

Test ID Reporting Name Available Separately Always Performed
CRETR Creatinine, Random, U Yes, (Order RCTUR) Yes
RBPR Retinol-Binding Protein, Random, U No Yes

Method Name

CRETR: Enzymatic Colorimetric Assay

RBPR: Immunonephelometry

Reporting Name

Retinol-Binding Protein, Random, U

Specimen Type

Urine

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 7 days
  Frozen  7 days

Reject Due To

  All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Reference Values

≥18 years: <190 mcg/g creatinine

Reference values have not been established for patients that are less than 18 years.

Method Description

Creatinine:

The enzymatic method is based on the determination of sarcosine from creatinine with the aid of creatininase, creatinase, and sarcosine oxidase. The liberated hydrogen peroxide is measured via a modified Trinder reaction using a colorimetric indicator. Optimization of the buffer system and the colorimetric indicator enables the creatinine concentration to be quantified both precisely and specifically.(Package insert: Creatinine plus ver 2. Roche Diagnostics; V16.0 02/2022)

 

Retinol-Binding Protein:

In an immunochemical reaction, urinary retinol-binding protein forms immune complexes with anti-retinol-binding protein-specific antibodies coated onto polystyrene latex particles. The resulting latex bead-antigen-antibody complexes have enhanced light-scattering ability, which is detected with a nephelometer when a beam of light is passed through the sample. The intensity of the scattered light is proportional to the concentration of retinol-binding protein in the sample. The result is evaluated by comparison with a standard of known retinol-binding protein concentration.(Package insert: Human Urine Retinol Binding Protein Nephelometric Kit for use on the Siemens BNII. The Binding Site Group Ltd; V27 11/2012)

Day(s) Performed

Monday, Wednesday, Friday

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

83883-Retinol -Binding Protein, Random, U

82570-Creatinine, Random, U

Forms

If not ordering electronically, complete, print, and send a Renal Diagnostics Test Request (T830) with the specimen.