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HelpOrder Code RPR14 Respiratory Profile, Region 14, Central California, Serum
Useful For
Assessing sensitization to various inhalant allergens commonly found in Central California
Defining the allergen responsible for eliciting signs and symptoms
Identifying allergens:
-Responsible for allergic response or anaphylactic episode
-To confirm sensitization prior to beginning immunotherapy
-To investigate the specificity of allergic reactions to insect venom allergens, drugs, or chemical allergens
This test is not useful for patients previously treated with immunotherapy to determine if residual clinical sensitivity exists or in whom the medical management does not depend upon identification of allergen specificity.
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| IGE | Immunoglobulin E (IgE), S | Yes | Yes |
| DP | House Dust Mites/D.P., IgE | Yes | Yes |
| DF | House Dust Mites/D.F., IgE | Yes | Yes |
| CAT | Cat Epithelium, IgE | Yes | Yes |
| DOGD | Dog Dander, IgE | Yes | Yes |
| BERG | Bermuda Grass, IgE | Yes | Yes |
| TIMG | Timothy Grass, IgE | Yes | Yes |
| COCR | Cockroach, IgE | Yes | Yes |
| PENL | Penicillium, IgE | Yes | Yes |
| CLAD | Cladosporium, IgE | Yes | Yes |
| ASP | Aspergillus Fumigatus, IgE | Yes | Yes |
| ALTN | Alternaria Tenuis, IgE | Yes | Yes |
| OLIV | Olive-Tree, IgE | Yes | Yes |
| ALDR | Grey Alder, IgE | Yes | Yes |
| CED | Mountain Cedar, IgE | Yes | Yes |
| OAK | Oak, IgE | Yes | Yes |
| ELM | Elm, IgE | Yes | Yes |
| ESYC | Eastern Sycamore, IgE | Yes | Yes |
| BIR | Silver Birch, IgE | Yes | Yes |
| MULB | Mulberry, IgE | Yes | Yes |
| SRW | Short Ragweed, IgE | Yes | Yes |
| MUG | Mugwort, IgE | Yes | Yes |
| RUSS | Russian Thistle, IgE | Yes | Yes |
| RRRP | Rough Pigweed, IgE | Yes | Yes |
Special Instructions
Reporting Name
Resp Profile, Reg 14, Central CASpecimen Type
SerumOrdering Guidance
For a listing of allergens available for testing, see Allergens - Immunoglobulin E (IgE) Antibodies.
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1.7 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
1.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 14 days |
| Frozen | 90 days |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
Reference Values
Specific IgE:
|
Class |
IgE kU/L |
Interpretation |
|
0 |
<0.10 |
Negative |
|
0/1 |
0.10-0.34 |
Borderline/equivocal |
|
1 |
0.35-0.69 |
Equivocal |
|
2 |
0.70-3.49 |
Positive |
|
3 |
3.50-17.4 |
Positive |
|
4 |
17.5-49.9 |
Strongly positive |
|
5 |
50.0-99.9 |
Strongly positive |
|
6 |
≥100 |
Strongly positive |
Concentrations of 0.70 kU/L or more (class 2 and above) will flag as abnormally high.
Reference values apply to all ages.
Total IgE:
|
Age |
Reference interval (in kU/L) |
|
0-5 months |
≤13 |
|
6-11 months |
≤34 |
|
1 and 2 years |
≤97 |
|
3 years |
≤199 |
|
4-6 years |
≤307 |
|
7 and 8 years |
≤403 |
|
9-12 years |
≤696 |
|
13-15 years |
≤629 |
|
16 and 17 years |
≤537 |
|
18 years and older |
≤214 |
Method Description
Specific IgE:
Specific IgE from the patient's serum reacts with the allergen of interest, which is covalently coupled to an ImmunoCAP. After washing away nonspecific IgE, enzyme-labeled anti-IgE antibody is added to form a complex. After incubation, unbound anti-IgE is washed away, and the bound complex incubated with a developing agent. After stopping the reaction, the fluorescence of the eluate is measured. Fluorescence is proportional to the amount of specific IgE present in the patient's sample (ie, the higher the fluorescence value, the more IgE antibody is present).(Package insert: ImmunoCAP System Specific IgE FEIA. Phadia; Rev 06/2020)
Total IgE:
Anti-IgE, covalently coupled to ImmunoCAP, reacts with the IgE in a serum specimen. After washing, enzyme-labeled anti-IgE antibodies are added to form a complex. After incubation, unbound enzyme-labeled anti-IgE is washed away, and the bound complex incubated with a developing agent. After stopping the reaction, fluorescence of the eluate in the well is measured. The fluorescence is directly proportional to the concentration of IgE in the test specimen.(Package insert: Phadia CAP System IgE FEIA. Phadia; Rev 10/2019)
Day(s) Performed
Monday through Friday
Performing Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
82785-IgE
86003 x 23-Each individual allergen
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| RPR14 | Resp Profile, Reg 14, Central CA | 48837-9 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| ALDR | Grey Alder, IgE | 15284-3 |
| ALTN | Alternaria Tenuis, IgE | 6020-2 |
| ASP | Aspergillus Fumigatus, IgE | 6025-1 |
| BERG | Bermuda Grass, IgE | 6041-8 |
| BIR | Silver Birch, IgE | 15283-5 |
| CAT | Cat Epithelium, IgE | 6833-8 |
| CED | Mountain Cedar, IgE | 6178-8 |
| CLAD | Cladosporium, IgE | 53760-5 |
| COCR | Cockroach, IgE | 6078-0 |
| DF | House Dust Mites/D.F., IgE | 6095-4 |
| DOGD | Dog Dander, IgE | 6098-8 |
| DP | House Dust Mites/D.P., IgE | 6096-2 |
| ELM | Elm, IgE | 6109-3 |
| ESYC | Eastern Sycamore, IgE | 6263-8 |
| IGE | Immunoglobulin E (IgE), S | 19113-0 |
| MUG | Mugwort, IgE | 6183-8 |
| MULB | Mulberry, IgE | 6281-0 |
| OAK | Oak, IgE | 6189-5 |
| OLIV | Olive-Tree, IgE | 6192-9 |
| PENL | Penicillium, IgE | 6212-5 |
| RRRP | Rough Pigweed, IgE | 6233-1 |
| RUSS | Russian Thistle, IgE | 6234-9 |
| SRW | Short Ragweed, IgE | 6085-5 |
| TIMG | Timothy Grass, IgE | 6265-3 |
Method Name
Fluorescence Enzyme Immunoassay (FEIA)
Forms
If not ordering electronically, complete, print, and send an Allergen Test Request (T236) with the specimen.