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HelpOrder Code RPR2 Respiratory Profile, Region 2, Mid-Atlantic (DC, DE, MD, NC, VA), Serum
Useful For
Assessing sensitization to various inhalant allergens commonly found in the Mid-Atlantic region including the District of Columbia, Delaware, Maryland, North Carolina, and Virginia
Defining the allergen responsible for eliciting signs and symptoms
Identifying allergens:
-Responsible for allergic response and/or anaphylactic episode
-To confirm sensitization prior to beginning immunotherapy
-To investigate the specificity of allergic reactions to insect venom allergens, drugs, or chemical allergens
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| IGE | Immunoglobulin E (IgE), S | Yes | Yes |
| DP | House Dust Mites/D.P., IgE | Yes | Yes |
| DF | House Dust Mites/D.F., IgE | Yes | Yes |
| CAT | Cat Epithelium, IgE | Yes | Yes |
| DOGD | Dog Dander, IgE | Yes | Yes |
| BERG | Bermuda Grass, IgE | Yes | Yes |
| TIMG | Timothy Grass, IgE | Yes | Yes |
| JOHN | Johnson Grass, IgE | Yes | Yes |
| COCR | Cockroach, IgE | Yes | Yes |
| PENL | Penicillium, IgE | Yes | Yes |
| CLAD | Cladosporium, IgE | Yes | Yes |
| ASP | Aspergillus Fumigatus, IgE | Yes | Yes |
| ALTN | Alternaria Tenuis, IgE | Yes | Yes |
| BXMPL | Box Eld/Maple, S, IgE | Yes | Yes |
| BIR | Silver Birch, IgE | Yes | Yes |
| CED | Mountain Cedar, IgE | Yes | Yes |
| OAK | Oak, IgE | Yes | Yes |
| ELM | Elm, IgE | Yes | Yes |
| CTWD | Cottonwood, IgE | Yes | Yes |
| PCANH | Pecan Hickory, IgE | Yes | Yes |
| MULB | Mulberry, IgE | Yes | Yes |
| SRW | Short Ragweed, IgE | Yes | Yes |
| RRRP | Rough Pigweed, IgE | Yes | Yes |
| SORR | Red Sorrel, IgE | Yes | Yes |
Special Instructions
Reporting Name
Resp Profile, Reg 2, Mid-AtlanticSpecimen Type
SerumOrdering Guidance
For a listing of allergens available for testing, see Allergens - Immunoglobulin E (IgE) Antibodies.
Specimen Required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1.7 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
1.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Frozen | 90 days |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
Reference Values
Specific IgE:
|
Class |
IgE kU/L |
Interpretation |
|
0 |
<0.10 |
Negative |
|
0/1 |
0.10-0.34 |
Borderline/equivocal |
|
1 |
0.35-0.69 |
Equivocal |
|
2 |
0.70-3.49 |
Positive |
|
3 |
3.50-17.4 |
Positive |
|
4 |
17.5-49.9 |
Strongly positive |
|
5 |
50.0-99.9 |
Strongly positive |
|
6 |
≥100 |
Strongly positive |
Reference values apply to all ages.
Total IgE:
|
Age |
Reference interval (in kU/L) |
|
0-5 months |
≤13 |
|
6-11 months |
≤34 |
|
1 and 2 years |
≤97 |
|
3 years |
≤199 |
|
4-6 years |
≤307 |
|
7 and 8 years |
≤403 |
|
9-12 years |
≤696 |
|
13-15 years |
≤629 |
|
16 and 17 years |
≤537 |
|
18 years and older |
≤214 |
Method Description
Specific IgE:
Specific IgE from the patient's serum reacts with the allergen of interest, which is covalently coupled to an ImmunoCAP. After washing away nonspecific IgE, enzyme-labeled anti-IgE antibody is added to form a complex. After incubation, unbound anti-IgE is washed away, and the bound complex incubated with a developing agent. After stopping the reaction, the fluorescence of the eluate is measured. Fluorescence is proportional to the amount of specific IgE present in the patient's sample (ie, the higher the fluorescence value, the more IgE antibody is present).(Package insert: ImmunoCAP System Specific IgE FEIA. Phadia; Rev 06/2020)
Total IgE:
Anti-IgE, covalently coupled to ImmunoCAP, reacts with the IgE in a serum specimen. After washing, enzyme-labeled anti-IgE antibodies are added to form a complex. After incubation, unbound enzyme-labeled anti-IgE is washed away, and the bound complex incubated with a developing agent. After stopping the reaction, fluorescence of the eluate in the well is measured. The fluorescence is directly proportional to the concentration of IgE in the test specimen.(Package insert: Phadia CAP System IgE FEIA. Phadia; Rev 10/2019)
Day(s) Performed
Monday through Friday
Performing Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
82785-IgE
86003 x 23-Each individual allergen
Method Name
Fluorescence Enzyme Immunoassay (FEIA)
Forms
If not ordering electronically, complete, print, and send an Allergen Test Request (T236) with the specimen.