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HelpOrder Code SEAFP Seafood Allergen Profile, Serum
Reporting Name
Seafood Allergen ProfileUseful For
Establishing a diagnosis of an allergy to seafood (cod, crab, lobster, shrimp, or tuna)
Defining the allergen responsible for eliciting signs and symptoms
Identifying allergens:
-Responsible for allergic response or anaphylactic episode
-To confirm sensitization prior to beginning immunotherapy
-To investigate the specificity of allergic reactions to insect venom allergens, drugs, or chemical allergens
This test is not useful for patients previously treated with immunotherapy to determine if residual clinical sensitivity exists or in whom the medical management does not depend upon identification of allergen specificity.
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| COD | Codfish, IgE | Yes | Yes |
| CRAB | Crab, IgE | Yes | Yes |
| SHRI | Shrimp, IgE | Yes | Yes |
| TUNA | Tuna, IgE | Yes | Yes |
| LOB | Lobster, IgE | Yes | Yes |
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
SerumOrdering Guidance
For a listing of allergens available for testing, see Allergens - Immunoglobulin E (IgE) Antibodies in Special Instructions
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 0.7 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 14 days |
| Frozen | 90 days |
Special Instructions
Reference Values
|
Class |
IgE kU/L |
Interpretation |
|
0 |
<0.10 |
Negative |
|
0/1 |
0.10-0.34 |
Borderline/equivocal |
|
1 |
0.35-0.69 |
Equivocal |
|
2 |
0.70-3.49 |
Positive |
|
3 |
3.50-17.4 |
Positive |
|
4 |
17.5-49.9 |
Strongly positive |
|
5 |
50.0-99.9 |
Strongly positive |
|
6 |
≥100 |
Strongly positive |
Concentrations of 0.70 kU/L or more (class 2 and above) will flag as abnormally high.
Reference values apply to all ages.
Day(s) Performed
Monday through Friday
CPT Code Information
86003 x 5
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| SEAFP | Seafood Allergen Profile | 49222-3 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| COD | Codfish, IgE | 6082-2 |
| CRAB | Crab, IgE | 6092-1 |
| LOB | Lobster, IgE | 6165-5 |
| SHRI | Shrimp, IgE | 6246-3 |
| TUNA | Tuna, IgE | 6270-3 |
Method Description
Specific IgE from the patient's serum reacts with the allergen of interest, which is covalently coupled to an ImmunoCAP. After washing away nonspecific IgE, enzyme-labeled anti-IgE antibody is added to form a complex. After incubation, unbound anti-IgE is washed away, and the bound complex incubated with a developing agent. After stopping the reaction, the fluorescence of the eluate is measured. Fluorescence is proportional to the amount of specific IgE present in the patient's sample (ie, the higher the fluorescence value, the more IgE antibody is present).(Package insert: ImmunoCAP System Specific IgE FEIA. Phadia; Rev 06/2020)
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
Method Name
Fluorescence Enzyme Immunoassay (FEIA)
Forms
If not ordering electronically, complete, print, and send an Allergen Test Request (T236) with the specimen.