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HelpOrder Code TAPNS Tapentadol and Metabolite, Serum
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Red top (Serum gel/SST are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 1.0 mL Serum
Collection Instructions: Within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.
Useful For
Monitoring medication compliance in patients who are prescribed tapentadol
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Reporting Name
Tapentadol and Metabolite, SSpecimen Type
Serum RedSpecimen Minimum Volume
Serum: 0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum Red | Refrigerated (preferred) | 14 days |
| Frozen | 28 days | |
| Ambient | 14 days |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Reference Values
Tapentadol:
Therapeutic: 5-300 ng/mL
N-desmethyltapentadol:
No therapeutic range established
Cutoff concentrations by liquid chromatography tandem mass spectrometry:
Tapentadol: 0.5 ng/mL
N-desmethyltapentadol: 0.5 ng/mL
Method Description
Serum samples are mixed with internal standard and extracted by protein crash with methanol. The supernatant after centrifugation is diluted with Clinical Laboratory Reagent Water. The sample is then analyzed by liquid chromatography tandem mass spectrometer.(Unpublished Mayo method)
Day(s) Performed
Tuesday
Performing Laboratory
Mayo Clinic Laboratories in Rochester
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| TAPNS | Tapentadol and Metabolite, S | In Process |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 624021 | Tapentadol | 59354-1 |
| 624022 | N-desmethyltapentadol | In Process |