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HelpOrder Code TOPIR Topiramate, Serum
Additional Codes
Mayo Test ID: TOPI
Reporting Name
Topiramate, SUseful For
Monitoring serum concentrations of topiramate
Assessing compliance
Assessing potential toxicity
Specimen Type
Serum RedSpecimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Red top (serum gel/SST are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL serum
Collection Instructions:
1. Draw blood immediately before next scheduled dose.
2. Within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
Serum: 0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum Red | Refrigerated (preferred) | 28 days |
| Ambient | 28 days | |
| Frozen | 28 days |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Reference Values
Anticonvulsant: 5.0-20.0 mcg/mL
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Day(s) Performed
Monday through Friday
CPT Code Information
80201
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| TOPI | Topiramate, S | 17713-9 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 81546 | Topiramate, S | 17713-9 |
Method Description
The serum sample is crashed with acetonitrile containing the deuterium labeled internal standard. The protein precipitate is centrifuged and a portion of the supernatant is diluted with Mobile Phase 1 for detection by tandem mass spectrometry (MS/MS).(Unpublished Mayo method)
Forms
If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:
-Neurology Specialty Testing Client Test Request (T732)
-Therapeutics Test Request (T831)